Features of the level of protection of the intestinal barrier in young children
https://doi.org/10.22627/2072-8107-2025-24-4-26-30
Abstract
The aim of the study is to identify the characteristics of the intestinal microbiocenosis and the level of protection of the intestinal barrier in young children with functional disorders of the digestive organs. Methods. The article presents a study of the intestinal microbiota using gas chromatography-mass spectrometry of microbial markers in 25 young children with functional disorders of the digestive system. Results. It was revealed that these were children at risk for the development of infectious and inflammatory diseases. All of them had a violation of the formation of intestinal microbiocenosis in the form of a deficiency of normal microbiota representatives with an excessive growth of opportunistic bacteria associations of 6—20 species. High levels of endotoxin were detected in 18 of the 25 children. Conclusion. A close relationship was established between the degree of intestinal microbiota imbalance and the concentration of endotoxin, which determines the basic level of inflammation and the level of protection of the intestinal barrier/increased permeability, as well as the degree of inflammatory changes in the coprogram.
About the Authors
O. V. Kovaleva
Orenburg State Medical University of the Ministry of Health of Russia; Medical Center «Dimetra»
Russian Federation
Russian Federation
Orenburg
L. A. Lityaeva
Orenburg State Medical University of the Ministry of Health of Russia
Russian Federation
Russian Federation
Orenburg
O. G. Zhilenkova
G.N. Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology of Rospotrebnadzor
Russian Federation
Russian Federation
Moscow
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Review
For citations:
Kovaleva O.V., Lityaeva L.A., Zhilenkova O.G. Features of the level of protection of the intestinal barrier in young children. CHILDREN INFECTIONS. 2025;24(4):26-30. (In Russ.) https://doi.org/10.22627/2072-8107-2025-24-4-26-30
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