Results of treatment of coxiellosis in children: a retrospective cohort study
https://doi.org/10.22627/2072-8107-2025-24-4-43-46
Abstract
Coxiellosis belongs to the group of zoonotic rickettsioses. One of the main foci of this rickettsiosis in the Russian Federation is the Astrakhan region. The clinical symptoms of coxiellosis are polymorphic, which presents significant difficulties for diagnosis, and a number of drugs recommended for the treatment of coxiellosis have age restrictions on use in children, which requires improved approaches to the treatment of this pathology. The aim of the study was to evaluate the effectiveness of treatment of coxyellosis in children with azithromycin as a monovariant and in combination with the immunopreparation meglumine acridone acetate (cycloferon). Мethods: the duration of the main symptoms of coxiellosis was analyzed: fever, scleroconjunctivitis, myalgia, hepatomegaly, the duration of the disease in children treated with azithromycin (n = 35) or azithromycin + meglumine acridone acetate (n = 35). The results. The duration of the main symptoms of coxyellosis (fever, scleroconjunctivitis, myalgia, hepatomegaly) in children treated with azithromycin+ meglumine acridone acetate had statistically significant differences with similar data in children treated with azithromycin alone (p < 0,050). Conclusion. Treatment of coxyellosis in children using azithromycin+meglumine acridone acetate is more effective than azithromycin monotherapy.
About the Authors
G. A. Kharchenko
Аstrakhan State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Astrakhan
O. G. Kimirilova
Аstrakhan State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Astrakhan
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Review
For citations:
Kharchenko G.A., Kimirilova O.G. Results of treatment of coxiellosis in children: a retrospective cohort study. CHILDREN INFECTIONS. 2025;24(4):43-46. (In Russ.) https://doi.org/10.22627/2072-8107-2025-24-4-43-46
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