The Value of Persistent Cytomegalovirus Infection in the Formation of Groups of Children with Recurrent Acute Respiratory Diseases
https://doi.org/10.22627/2072-8107-2015-14-4-13-16
Abstract
So far not defined the value of CMV persistence in frequently and chronically ill children, the impact of active CMV-infection on the severity of the condition and the incidence of viral-bacterial complications. 149 surveyed frequently and long ill children with lymphadenopathy (58), obstructive bronchitis (40), the defeat of the
ENT organs (18), meningoencephalitis (13), pleuropneumonia (12), thrombocytopenia (8), were in the offices MDKB. The age of the children ranged from 1 month. up to 14 years. Structural identification of CMV pp65 antigen is recommended in severe patients and in children with frequent and prolonged acute respiratory infections, complications of purulent-inflammatory diseases. To confirm active CMV replication method should be used in real time PCR in saliva and urine (positive at 48.6%).
About the Authors
I. A. SotnikovRussian Federation
assistant of the Department of infectious diseases in children of pediatric faculty, Pirogov Russian National Research Medical University; Russian Federation, 117997, Moscow, Ostrovityanova str., 1
N. Yu. Egorova
Russian Federation
E. A. Valtz
Russian Federation
E. V. Chichaev
Russian Federation
A. A. Kusch
Russian Federation
References
1. Illy R., Von Mutius E., Lau S. [The role of early childhood ifections diseases in the development of asthma up to school age] // Allerg. and Clin.Immunol. 2001. Vol.13. №3. Р. 99—106.
2. Заболеваемость по результатам профилактических медицинских осмотров детей дошкольного и младшего школьного возраста, посещающих образовательные учреждения Южного административного округа Москвы / Рапопорт И.К. и др. // Российский вестник перинатологии и педиатрии. 2005. № 1. С. 5—8. [Morbidity according to the results of preventive medical examinations of children of preschool and younger school age attending educational institutions of the southern administrative district of Moscow] / Rapoport I.K. and others // Russian Vestnik of Perinatology and Pediatrics. 2005. № 1. P. 5—8. (In Russ.).
3. Britt W.J., Mach M. [Human cytomegalovirus glycoproteins] // Intervirology. — 1996. — Vol.39. — P. 401—412.
4. Crough T, Khanna R. [Immunobiology of Human Cytomegalovirus: from Bench to Bedside] // Clin. Microbiol. Rev. — 2009. —Р. 76—98.
5. Knipe D.M., Samuel C.E., Palese P. [Virus — host cell interactions] // Fields virology / Ed. by D.M. Knipe et al. — Lippincott-Raven, Philadelphia, 2001. P. 133—170.
6. Samuel C.E. [Antiviral actions of interferons] // Clin. Microb. Rev. 2001. Vol. 14. P. 778—809.
7. Taylor R.T., Bresnahan W.A. [Human cytomegalovirus immediateearly 2 gene expression blocks virus-induced beta interferon production] // J. Virol. 2005. Vol. 79. P. 3873—3877.
8. Abate D.A., Watanabe S., Mocarski E.S. [Major human cytomegalovirus structural protein pp65 (ppUL83) prevents interferon response factor 3 activation in the interferon response] // J. Virol. 2004. Vol. 78. P. 10995—11006.
9. Ройт А. Иммунология. Пер. с англ. — М: Мир, 2007. С. 592. Royt A. [Immunology]. TRANS. angl. — M: The World, 2007. P. 592. (In Russ.).
10. Spaete R.R., Gehrz R.C., Landini M.P. [Human cytomegalovirus structural proteins] // J. Gen. Virol. 1994. Vol. 75. P. 3287—3308.
11. Meyer J.D., Ljungman P., Fisher L.D. [Cytomegalovirus excretion as a predictor of cytomegalovirus disease after marrow transplantation: importance of cytomegalovirus viremia] // J. Infect. Dis. 1990. V. 162. P. 373—380.
12. Tanabe K., Tokumoto T., Ishikawa N. [Comparative study of cytomegalovirus (CMV) antigenemia assay polymerase chain reaction, serology and shell vial assay in the early diagnosis and moni toring of CMV infection after renal transplantation] // Transplantation. 1997. Vol. 64. Р. 1721—1725.
13. [Antigenemia in the diagnosis and monitoring of active cytomegalovirus infection after liver transplantation] / Van den Berg A. P. et al. // J. Infect. Dis. 1991. Vol.164. Р. 265—270.
14. Boeckh M., G. Boivin. [Quantitation of cytomegalovirus: methodologic aspects and clinical applications] // Clinical Microbiol. Rewiews. 1998. Vol. 11. № 3. P. 533—554.
15. [Direct detection of cytomegalovirus in peripheral blood leukocytes — a review of the antigenemia assay and polymerase chain reaction] / Van der Ploeg М. et al. // Transplantation. 1992. Vol. 54. Р. 193—198.
16. [Diagnosing cytomegalovirus disease in CMV seropositive renal allograft recipients: a comparison between the detection of CMV DNAemia by polymerase chain reaction and antigenemia by CMV pp65 assay] / Lo C. Y. et al. // Clin. Transplant. 1997. Vol. 11. Р. 286—293.
Review
For citations:
Sotnikov I.A., Egorova N.Yu., Valtz E.A., Chichaev E.V., Kusch A.A. The Value of Persistent Cytomegalovirus Infection in the Formation of Groups of Children with Recurrent Acute Respiratory Diseases. CHILDREN INFECTIONS. 2015;14(4):13-16. (In Russ.) https://doi.org/10.22627/2072-8107-2015-14-4-13-16