THE STRUCTURE OF THE VIRAL TRIGGERS OF FEBRILE SEIZURES IN CHILDREN OF EARLY AGE
https://doi.org/10.22627/2072-8107-2016-15-3-5-10
Abstract
The study presents the results of clinical and laboratory observations 121 children aged 3 to 36 months with the diagnosis «ARVI with convulsive syndrome». The prevalence of patients with burdened hereditary anamnesis for the development of febrile seizures (FS) (31.4 ± 4.2%). During the laboratory examination along with the respiratory viruses group noted the high herpes virus infection (51.2%), particularly human herpes virus 6 type (of 38.7%). The extension of the spectrum of the diagnostic examination of children with FS will establish the role of infectious triggers in the occurrence of FS and thereby define rational tactics and dispensary observation of this group of patients.
About the Authors
M. A. Stroganova
Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation
Russian Federation
G. P. Martynova
Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation
Russian Federation
Martynova Galina — MD, Professor, Head of Department of Pediatric Infectious Diseasesэ.
660022, Krasnoyarsk, ul. Partizan Zheleznyaka, 1; +7 (913) 534-85-27, doc-martynova@yandex.ruN. A. Shnayder
Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation
Russian Federation
A. A. Kolodina
Krasnoyarsk Interdistrict Clinical Hospital №1, Krasnoyarsk
Russian Federation
Russian Federation
References
1. Mukhin K.Yu. [Febrile seizures (lecture)] // Rus. Zhurn. Det. Nevrologii. 2010. V. 5, № 2. Р. 17—29. (In Russ).
2. Patterson J.L., Carapetian S.A., Hageman J.R., Kelley K.R. Febrile seizures // Pediatr Ann. 2013. 42(12): 249—254.
3. Engel J.Jr. A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: Report of the ILAE task Force on Classification and Terminology // Epilepsia. 2001. Vol. 42 (6). P. 796—803.
4. Mironov M.B., Muhin K.Yu. [Outcomes and transformation of febrile seizures in children, according to the Institute of child neurology and epilepsy name of St. Luke] // Rus. Zhurn. Det. Nevrologii. 2012. V.. 7. № 4. Р. 3—16. (In Russ.)
5. Kaputu Kalala Malu C., Mafuta Musalu E., Dubru J.M. et al. Epidemiology and characteristics of febrile seizures in children // Rev. Med. Liege. 2013; 68 (4): 180—185.
6. Mohammadi M. Febrile seizures: Four Steps Algorithmic Clinical Approach // Iran J. Pediatr. 2010. Vol. 20(1). P. 5—15.
7. Stroganova M.A., Shnayder N.A., Martynova G.P., Dyuzhakova A.V. [Epidemiology of febrile seizures (review)] // V mire Nauchnyih Otkryitiy. 2014. №8 (56). Р. 216—231 (In Russ).
8. Shnayder N.A., Shapovalova E.A., Dmitrenko D.V. [Epidemiology of pediatric epilepsy] // Sibirskoe Meditsinskoe Obozrenie. 2012. № 2. Р. 44—50. (In Russ).
9. Shelkovskiy V.I., Studenikin V.M., Maslova O.I., Mazurina E.M. [The problem of febrile seizures in children] // Voprosyi Sovremennoy Pediatrii. 2005. № 4 (4). Р. 50—53. (In Russ).
10. Trepilets V.M., Golosnaya G.S., Schederkina I.O., Trepilets S.V., Koltunov I.E. [Simple febrile seizures in pediatric practice and a pediatric neurologist: features of the flow and the risk of developing epilepsy] // Pediatriya. 2014. V. 93. № 1. Р. 65—67. (In Russ).
11. Studenikin V.M., Tursunhuzhaeva S.Sh., Shelkovskiy V.I., Pak L.A. [Febrile convulsions in children: theoretical and practical aspects] // Voprosyi Рrakticheskoy Рediatrii. 2010. V. 5. № 2. Р. 66—74. (In Russ).
12. Stroganova M.A., Shnayder N.A., Martyinova G.P., Dyuzhakova A.V. [Febrile seizures in children] // Spravochnik Vracha Obschey Praktiki. 2014. № 12. Р.47—55. (In Russ).
13. Hirose S., Mohney R.P., Okada M. et al. The genetics of febrile seizures and related epilepsy syndromes // Brain Develop. 2003; 25 (5): 304—312.
14. Mukhin K.Yu., Petruhin A.S., Mironov M.V. [Epileptic syndromes: Diagnosis and treatment]. — M., 2008. — 223 р. (In Russ).
15. Shamansurov Sh.Sh., Mirsaidova N.A., Abdukadyirova N.M. [A hereditary factor in children with febrile convulsions] // Vrach-aspirant. 2010. V. 39. № 2.1. Р. 189—194. (In Russ).
16. Nakayama J., Arinami T. Molecular genetics of febrile seizures // Epilepsy research. 2006. № 70. Р. 190—198.
17. Dmitrenko D.V., Shnayder N.A., Martyinova G.P., Stroganova M.A. et al. [Mutations of sodium channels as a genetic predictor of febrile seizures in children] // Sovremennyie Problemyi Nauki i Obrazovaniya. 2015. № 5; URL: www.science-education.ru/128-22774. — Moskva, Akademiya estestvoznaniya. — 2015 (In Russ).
18. Lehtimäki KA I., Keränen T., Palmio J., Peltola J. Levels of IL-1beta and IL-1ra in cerebrospinal fluid of human patients after single and prolonged seizures // NeuroImmunoModulation. 2010. Vol. 17, № 1. Р. 19—22.
19. Serdaroglu G., Alpman A., Tosun A., Pehlivan S., Ozkinay F., Tekgul H., Gokben S. Febrile seizures: interleukin 1beta and interleukin-1 receptor antagonist polymorphisms // Pediatric Neurology. 2009 Vol. 40, № 2. Р. 113—116.
20. Zhen-Qiang Wu, Liang Sun, Ye-Huan Sun, Cizao Ren, Yu-Hong Jiang, Xiao-Ling Lv. Interleukin 1 beta 2511 C/T gene polymorphism and susceptibility to febrile seizures: a meta-analysis // Molecular Biology Reports. 2012. Vol. 5, № 39. Р. 5401—5407.
21. Savenkova M.S. [The many faces of acute respiratory infection: from basic agents to the choice of drugs] // Lechaschiy Vrach. 2011. №3. Р. 58—64 (In Russ).
22. Skripchenko N.V., Krivosheenko E.M., Komantsev V.N. et al. [Heterogeneity of convulsive syndrome in children with infectious diseases] // Rossiyskiy Vestnik Рerinatologii i Рediatrii. 2012. V. 57, № 6. Р. 50—58. (In Russ).
23. Chung B., Wong V. Relationship between five common viruses and febrile seizure in children // Arch. Dis. Child. 2007. Vol. 92. P. 589—593.
24. Mashina N.S., Galaktionova M.Yu. [Health status of infants and its determining factors] // Sibirskoe Meditsinskoe Obozrenie. 2015. № 2 (92). Р. 26—31. (In Russ).
25. Stenina O.I., Uglitskih A.K., Paunova S.S. [The etiology and structure of convulsive syndrome in children during the first two years of life] // Pediatriya. 2013. №1. Р. 77—83 (In Russ).
26. Nikolskiy M.A. [Clinical variants of primary infection caused by viruses of the human herpes of 6-th and 7-th types, in children of early age] // Pediatriya. 2008 (87), № 4. Р. 52—55. (In Russ).
27. Hoecker C.C., Kaneyage J.T. Recurrent febrile seizures: an unusual presentation of nutritional rickets // J. Emerg. Med. 2002; 23:367—370.
28. Vashura L.V., Savenkova M.S., Savenkov M.P., Kalugina M.Yu., Karazhas N.V., Ryibalkina T.N., Samsonovich I.R. [The value of the virus of herpes of 6-th type in the Genesis of seizures in children] // Detskie Infektsii. 2014. № 4. Р.18—23 (In Russ).
29. Shnayder N.A., Martyinova G.P., Stroganova M.A., Dyuzhakova A.V., Dmitrenko D.V., Shapovalova E.A., Panina Yu.S. [Febrile seizures as a trigger mesial temporal sclerosis: a clinical case] // Problemyi Zhenskogo Zdorovya. 2015 (10), № 1. Р. 69—78. (In Russ).
30. Donati D., Akhyani N. et al. Detection of human herpesvirus-6 in mesial TLE surgical brain resections // Neurology. 2003. V. 61. P. 1405—1411.
31. Dekonenko E.P. [Herpes encephalitis: difficulties of differential diagnostics] // Klinicheskaya Nevrologiya. 2009. № 1. Р. 35—40. (In Russ).
32. Shnayder N.A., Kamzalakova N.I., Kryizhanovskaya S.V., Panina Yu.S. [Possible ways of optimization of diagnostic care for patients with symptomatic epilepsy on the background of chronic herpes encephalitis] // Epilepsiya i Рaroksizmalnyie Sostoyaniya. 2015. № 2. Р. 6—17. (In Russ).
Review
For citations:
Stroganova M.A., Martynova G.P., Shnayder N.A., Kolodina A.A. THE STRUCTURE OF THE VIRAL TRIGGERS OF FEBRILE SEIZURES IN CHILDREN OF EARLY AGE. CHILDREN INFECTIONS. 2016;15(3):5-10. (In Russ.) https://doi.org/10.22627/2072-8107-2016-15-3-5-10
Views:
1649
Email this article 