TACTICS OF BIOCENOSIS-SAVING THERAPY BY USE ANTIBIOTICS IN CHILDREN WITH ACUTE INTESTINAL INFECTIONS
https://doi.org/10.22627/2072-8107-2017-16-3-41-49
Abstract
50 children aged from 3 to 67 months with acute intestinal infections receiving antibiotic therapy, were clinically and microbiologically examined using gas-liquid chromatographic test with the measurement of short-chain fatty acids (SCFAs) in coprofiltrates. The influence on the biocenosis is assessed upon treatment with an-tidiarrhoeal medication Gelatin tannat (Adiarin), which acts by forming a protective film on the surface of intestinal mucosa preventing loss of body fluids and microbial toxins. 20 children in the control group received antibiotics, sorbents, probiotics. The study has proved the clinical effect of Gelatin tannat, resulting in reduction of time to normalization of diarrhea and intoxication for 2 days, and data on the probiotic effect of the drug, similar to that of probiotics in the control group which expands the indications for the use of Gelatin tannat for prevention of antibiotic-associated diarrhea.
About the Authors
L. N. Mazankova
Department of Pediatric Infiectious Diseases, Russian Medical Academy of Postgraduate Education, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
MD, Professor, Department of Infectious Diseases
A. A. Korsunsky
City Children’s Hospital № 9 named after G.N. Speransky, Moscow
Russian Federation
Russian Federation
A. P. Prodeus
Russian National Research Medical University named after N.I. Pirogov
Russian Federation
Russian Federation
M. D. Ardatskaya
Educational and Research Medical Center in the Administrative Department of the President of the Russian Federation
Russian Federation
Russian Federation
S. G. Perlovskaya
City Children’s Hospital № 9 named after G.N. Speransky, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Mazankova L.N., Korsunsky A.A., Prodeus A.P., Ardatskaya M.D., Perlovskaya S.G. TACTICS OF BIOCENOSIS-SAVING THERAPY BY USE ANTIBIOTICS IN CHILDREN WITH ACUTE INTESTINAL INFECTIONS. CHILDREN INFECTIONS. 2017;16(3):41-49. (In Russ.) https://doi.org/10.22627/2072-8107-2017-16-3-41-49
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