THE ROLE OF CYTOKINES TNF-Α, IFN-Γ, IL-1, IL-4, IL-8 IN THE IMMUNE RESPONSE IN INFECTIOUS LESIONS OF CNS IN CHILDREN
https://doi.org/10.22627/2072-8107-2018-17-1-17-22
Abstract
In recent years, a lot of attention has been paid to studying the level of cytokines in various infectious pathologies, since this scientific direction is rightly promising and justified. The article presents literature data on the significance of the cytokine link in the immune response and the results of our own observations of 108 patients aged 3 to 17 years with enteroviral meningitis. In addition to the standard diagnostic plan, all patients underwent immunological examination of blood serum in the acute phase of the disease in order to assess the level of cytokines (TNF-α, IFN-γ, IL-1, IL-4, IL-8). The analysis of the obtained data made it possible to establish correlations of different levels between the values of cytokines and other parameters.
About the Authors
S. N. Eshmolov
Yaroslavl State Medical University of the Ministry of Health of the Russian Federation.
Russian Federation
Russian Federation
Sergey Eshmolov, PhD, Assistant of the Department of Infectious Diseases, Epidemiology and Children's Infections.
Yaroslavl.
I. G. Sitnikov
Yaroslavl State Medical University of the Ministry of Health of the Russian Federation.
Russian Federation
I. Sitnikov, MD, Professor, Head of the Department of Infectious Diseases, Epidemiology and Pediatric Infections. Yaroslavl.
Russian Federation
I. Sitnikov, MD, Professor, Head of the Department of Infectious Diseases, Epidemiology and Pediatric Infections. Yaroslavl.
I. M. Melnikova
Yaroslavl State Medical University of the Ministry of Health of the Russian Federation.
Russian Federation
Russian Federation
I. Melnikova, MD, Professor, Head of the Department of Hospital Pediatrics.
Yaroslavl.
References
1. Yarilin A.A. Immunology. M .: GEOTAR-Media, 2010.:752. (In Russ.)
2. Zheleznikova G.F. The role of cytokines in the pathogenesis and diagnosis of infectious diseases. Infectious diseases. 2008; 6(3):70— 76. (In Russ.)
3. Ignatov P.E. Immunity and infection. М.:Time. 2002:352. (In Russ.)
4. Batskalevich N.A., Verevshchikov V.K., Lagereva Yu.G. Evaluation of immunity and immunotropic therapy of enteroviral meningitis. Infectious diseases. 2009; 7(3):30—34. (In Russ.)
5. Roit A. et al. Immunology. Moscow: Mir, 2000:592. (In Russ.)
6. Khaitov P.M., Pinegin B.V., Cheredov A.K. Evaluation of the human immune system: the current state of the problem, complexity and achievements. Immunology. 2000; 6:8—10. (In Russ.)
7. Ketlinsky S.A., Simbirtsev A.C. Cytokines. St. Petersburg: «Folio». 2008: 549. (In Russ.).
8. Kozlov V.A. Some Aspects of the Problem of Cytokines. Cytokines and inflammation. 2002; 1(1):5—8. (In Russ.)
9. Simbirtsev A.C. Cytokines: classification and biological functions. Cytokines and inflammation. 2004; 3(2):16—22. (In Russ.)
10. Sorokina M.N., N.V. Skripchenko. Viral encephalitis and meningitis in children: A guide for doctors. Moscow: Publishing House «Medicine», 2004:416. (In Russ.)
11. Skripchenko N.V., Ivanova M.V., Ivanova G.P. at al. Actual problems of infectious diseases of the nervous system in children. Pediatrics. 2007; 86(1):101—113. (In Russ.)
12. Kimirilova O.G., Kharchenko G.A., Kimirilov A.A. Immunoglobulinotherapy of enteroviral meningitis in children. Russian Journal of Perinatology and Pediatrics. 2016; 61(2): 79—83. (In Russ.)
13. Ivashkin V.T., Yu.O. Shul'pekova, E.A. Lukin. Classical proinflammatory cytokines and their biological effects in liver diseases. Molecular medicine. 2003; 3:34—43. (In Russ.)
14. Insanov A.B., N.A. Fejzullaeva. Humoral and cellular immunity with meningitis of different etiology. Problems of tuberculosis. 2000; 2:21—23. (In Russ.)
15. Borisova E.Yu., Lavrov A.E., Tolkacheva N.I., Voevodina A.N. Features of the cytokine profile in children with pathology of the gastrointestinal tract with food allergies in different age periods. Cytokines and inflammation. 2015; 14(1):91—95. (In Russ.)
16. Eshmolov S.N., Sitnikov I.G., Melnikova I.M. Clinico-epidemiological and immunological features of enteroviral meningitis in children in the Yaroslavl region. Detskiye Infektsii=Children's Infections. 2012; 11(1):17—20. (In Russ.)
17. Freidlin I.S. The immune system and its defects: A guide for doctors. SPb.: NTFF «Polisan», 1998:113. (In Russ.)
18. Sibiryak S.V. Cytokines as regulators of cytochrome P-450-dependent monooxygenases. Theoretical and applied aspects. Cytokines and inflammation. 2003;2:25—28. (In Russ.)
19. Berezhnaya N.M. Cytokine regulation in pathology: rapid development and inevitable issues. Cytokines and inflammation. 2007;2:26—34. (In Russ.)
20. Babik R.K., Nikushkina K.V., Babik Т.М. Assessment of the level of cytokines in children with manifest and latent intrauterine herpes infections. Cytokines and inflammation. 2014;13(1):34—36. (In Russ.)
21. Vasilyeva G.I., I.A. Ivanova, S. Yu. Tyukavkina. Cytokines — the general system of homeostatic regulation of cellular functions. Cytology. 2001;12:1101—1109. (In Russ.)
22. Endler G. et al. Polymorphisms in the interleukin 1 gene cluster in children and young adults with systemic meningococcemia. Clin. Chem. 2006; Mar., 3:511.
23. Zmushko E.V., E.S. Belozerov, Yu.A. Mitin. Clinical Immunology: AGuide for Physicians. St. Petersburg: Peter, 2001: 576. (In Russ.)
24. Khaitov P.M., B.V. Pinegin. Assessment of human immune status in normal and pathological conditions. Immunology. 2001; 4:4—6. (In Russ.)
25. Molotchny V.P., Novik E.S., Obukhova G.T. Cytokine status of cerebrospinal fluid in children with meningococcal and enterovirus meningitis. Detskiye Infektsii=Children's Infections. 2007;6(2):10—12. (In Russ.)
Review
For citations:
Eshmolov S.N., Sitnikov I.G., Melnikova I.M. THE ROLE OF CYTOKINES TNF-Α, IFN-Γ, IL-1, IL-4, IL-8 IN THE IMMUNE RESPONSE IN INFECTIOUS LESIONS OF CNS IN CHILDREN. CHILDREN INFECTIONS. 2018;17(1):17-22. (In Russ.) https://doi.org/10.22627/2072-8107-2018-17-1-17-22
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