CLINICAL AND ETIOLOGICAL CHARACTERISTICS OF ACUTE RESPIRATORY VIRAL INFECTIONS IN HOSPITALIZED CHILDREN OF THE CITY OF KHABAROVSK IN EPIDEMIC SEASONS 2014—2017

The article presents the results of etiological diagnostics of cases of acute respiratory viral infections (ARVI) in children during the epidemic periods of 2014—2017, the material sampling was carried out at the Children's regional clinical hospital named after A.K. Piotrovich. Comparative material on the three seasons: 2014—2015, 2015—2016 and 2016—2017 years. The features of the annual dynamics of the frequency of allocation of various respiratory viruses are revealed. The most numerous group of patients was children first year of life (infants) — 154 (35.6 ± 2.3%). Among the hospitalized children prevailed patients with moderate severity (of 90.9 ± 1.3%). The causative agent was determined in 307 of 432 observed patients (71 ± 2.1%). It is shown that the predominant viral pathogen in all seasons is the rhinovirus. Among cases of community-acquired pneumonia the dominant pathogen is respiratory syncytial virus. Bocaviruses, metapneumoviruses and coronaviruses were more often found in the form of association with other viruses. The circulation of the influenza virus was accompanied by a decrease in the attention of other respiratory viruses.

1. Acute respiratory infections in children and adolescents: Practice guidelines for physicians. Under the editorship of L.V. Osidak. S-Pb.: Inform.Med, 2014:255. (In Russ.)

2. Nosulya E.V. Acute respiratory-viral infection — the complexity of diagnosis and treatment. Medical Advice. 2013; 3: 20—26. (In Russ.)

3. Borisov L.B. Medical Microbiology, Virology, Immunology: A Textbook. M.: «Medical Information Agency», 2001: 736. (In Russ.)

4. Uchaikin V.F., Shamsheva O.V., Molochkova O.V., Bulgakova V.A. Pharmacological and Epidemiological Study of the Course of Influenza and Other ARVI in the Season 2010/11 in Children under the Age of 18. Detskie Infektsii=Children's Infections. 2012;11:9—15. (In Russ.) https://doi.org/10.22627/2072-8107-2012-11-0-9-15]

5. Yanina M.A., Komissarov A.B., Osidak L.V, Lvov N.I. Detection of adenoviral genotypes in specimens from patients with ARVI. Molecular diagnostic: Collection of research papers. pub. MBA. 2014; 1:336. (In Russ.)

6. Tatochenko V., Uchaikin V., Gorelov A. et al. Epidemiology of respiratory syncytial virus in children ≤ 2 years of age hospitalized with lower respiratory tract infections in the Russian Federation: a prospective, multicenter study. Clinical Epidemiology. 2010, October 21; 2:221—227.

7. Uchaikin V., Shamsheva O., Bulgakova V., Molochkova O., Prostyakov I., Osipova E. Clinical and Epidemiologycal Features of Post Pandemic Influenza and Common Cold in Children in Russia. (Thesis report). In the book: Abstracts from the International Congress of Pediatric. 2013 (ICP): 2389—2390.

8. Harlamovа F.S., Kladova O.V., Uchaykin V.F., Cheshik S.G., Vartanyan R.V., Yablonskaya K.P. Metapneumovirus and bocavirus respiratory infections in the structure of SARS in children. Detskie Infektsii=Children's Infections. 2015;14(2):5-11. (In Russ.) https://doi.org/10.22627/2072-8107-2015-14-2-5-11

9. Dawood F.S. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N. Engl. J. Med. 2009, 360(25):2605— 2615.

10. Dondurey E.A, Suhovetskaya V.F., Osidak L.V et al. Influenza in children after a pandemic in a general hospital of St. Petersburg. Infekcija i Immunitet. 2014; 4(3): 257-266. ( In Russ.)

11. Timchenko V.N., Afanas'eva O.I., Dondurey E.A., Bulina O.V., Afanas'eva V.S., Pochinyaeva L.M., Gorbunov E.F. Pandemic Influenza A (H1N1) PDM 09 in the Season 2015/2016: Analysis of Fatal Outcomes in Children. Detskie Infektsii=Children's Infections. 2017; 16(1):36—42. (In Russ.) https://doi.org/10.22627/2072-8107-2017-16-1-36-42

12. Sukhovetskaya V.F., Osidak L.V., Afanasyeva V.S., Timchenko V.N., Afanasyeva O.I., Dondurey E.A., Obraztsova E.V., Kaplina T.A. Acute stenosing laryngotracheitis in respiratory viral monoinfections in children hospitalized in the clinics of St. Petersburg. Detskie Infektsii=Children's Infections. 2017;16(3):19—23. (In Russ.) https://doi.org/10.22627/2072-8107-2017-16-3-19-23