PARAMETERS OF ANTIVIRAL IMMUNITY IN NEWBORNS WITH CYTOMEGALOVIRUS INFECTION IN CASES OF LATE DETECTION OF CYTOMEGALOVIRUS DNA
https://doi.org/10.22627/2072-8107-2018-17-3-34-37
Abstract
Objective: study of immune status indices in newborns in cases of late detection of cytomegalovirus (CMV) DNA in blood and urine.
Methods: 147 newborns with non-specific clinical symptoms were studied. Тyping of lymphocytes relating to different clusters CD3+, CD69+, CD71+, CD95+ using monoclonal antibodies produced by IMMUNOTECH (France) have been performed. Expression of membrane markers of immunocompetent cells was measured on a laser flow cytofluorometer Beckman COULTER Epics XL II.
Results: In 123 newborns CMVI has been confirmed by the positive result of PCR, while in 24 newborns the negative result was obtained. In 24 three-month old babies, who had a negative result following DNA diagnostics in the first month of their life, cytomegalovirus in blood and urine and increase of anti-CMV IgG have been found, which allowed to diagnose CMVI.
The following formula reflecting the dependence of CMVI on CD69+ and CD95+ content in newborns having non-specific clinical symptoms in cases of late detection of CMV DNA has been offered.
About the Author
L. V. Kravchenko
Rostov State Medical University
Russian Federation
Russian Federation
Larisa V. Kravchenko - MD, lead researcher of the department of pediatric.
Rostov-on-Don.
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Review
For citations:
Kravchenko L.V. PARAMETERS OF ANTIVIRAL IMMUNITY IN NEWBORNS WITH CYTOMEGALOVIRUS INFECTION IN CASES OF LATE DETECTION OF CYTOMEGALOVIRUS DNA. CHILDREN INFECTIONS. 2018;17(3):34-37. (In Russ.) https://doi.org/10.22627/2072-8107-2018-17-3-34-37
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