Limbic autoimmune encephalitis with antibodies to glutamate decarboxylase (GAD)
https://doi.org/10.22627/2072-8107-2020-19-2-67-71
Abstract
Limbic encephalitis (LE) is a rare neurological syndrome, in most cases has a paraneoplastic nature, but recently there has been a large number of observations of idiopathic autoimmune LE associated with antibodies to neuronal membrane proteins. A clinical case of a disease in a 13-year-old patient with the detection of antibodies to glutamate decarboxylase (GAD) is described. The debut of the disease is marked by a decrease in memory for current events after the first convulsive attack during 2 months.
About the Authors
L. U. UlukhanovaRussian Federation
Lala Ulukhanova Lala, MD, head of the department of propaedeutics of childhood diseases with a course of childhood infections
Makhachkala
M. M. Yaraliev
Russian Federation
head of the intensive care unit
Makhachkala
S. M. Attaeva
Russian Federation
neurologist
Makhachkala
References
1. Anderson N.E., Barber P.A. Limbic encephalitis — a review. J. Clin. Neurosci. 2008; 15: 961—71.
2. Boronat A., Sabater L., Saiz A. et al. GABA(B) receptor antibodies in limbic encephalitis and anti-gad-associated neurologic disorders. Neurology. 2011; 76: 795—800.
3. Gultekin S.H., Rosenfeld M.R., Voltz R. et al. Paraneoplastic limbic encephalitis: neurological symptoms, immunological fi ndings and tumour association in 50 patients. Brain. 2000; 123: 1481—94.
4. Schott J.M. Limbic encephalitis: A clinician’s guide. Pract. Neurol. 2006; 6: 143—53.
5. Tüzün E., Dalmau J. Limbic encephalitis and variants: classifi cation, diagnosis and treatment. Neurologist. 2007; 13: 261—71.
6. Lancaster E., Martinez-Hernandez E., Titulaer M.J. et al. Antibodies to metabotropic glutamate receptor 5 in the Ophelia syndrome. Neurology. 2011; 77(18):1698—701. doi: 10.1212/WNL.0b013e3182364a44
7. Malter M.P., Helmstaedter C., Urbach H. et al. Antibodies to glutamic acid decarboxylase define a form of limbic encephalitis. Ann. Neurol. 2010; 67: 470—8.
Review
For citations:
Ulukhanova L.U., Yaraliev M.M., Attaeva S.M. Limbic autoimmune encephalitis with antibodies to glutamate decarboxylase (GAD). CHILDREN INFECTIONS. 2020;19(2):67-71. (In Russ.) https://doi.org/10.22627/2072-8107-2020-19-2-67-71