Polymorphisms rs231775 and rs5742909 CTLA-4 gene and their associative relations with chronic HBV infection in children
F. I. Inoyatova,
G. Z. Inogamova,
F. G. Abdullaevа,
N. K. Valievа,
N. A. Ikramova,
H. M. Kadyrhodzhaevа,
A. Kh. Akhmedovа https://doi.org/10.22627/2072-8107-2020-19-3-15-18
Abstract
The study of the genetic polymorphism rs231775 (+ 49A > G) and rs5742909 (+ 3 18С > Т) of the CTLA-4 gene in 100 children with chronic HBV infection revealed associations only with the carriage of the + 49A/ G polymorphic variant. Moreover, the carriage of the G allele in the homozygous mutant + 49GG position suggested the development of pronounced forms with a progressive course and a high probability of the outcome of the disease in cirrhosis.
The established gender differences — the boys' high expression of the minor G-allele of the CTLA-4 gene, especially in the homozygous mutant variation + 49GG — proves the phenomenon of a high incidence of hepatotropic viral infection in boys.
Therefore, the carriage of mutant variation + 49GG can be considered among the HOST factors for predicting adverse outcomes of chronic HBV infection in children.
About the Authors
F. I. Inoyatova
Republican Specialized Scientific and Practical Medical Center of Pediatrics, MH Ruz
Uzbekistan
Uzbekistan
Flora Inoyatova - MD, Head of the Department of Hepatology.
Tashkent
G. Z. Inogamova
Republican Specialized Scientific and Practical Medical Center of Pediatrics, MH Ruz
Uzbekistan
Uzbekistan
PhD
Tashkent
F. G. Abdullaevа
Republican Specialized Scientific and Practical Medical Center of Pediatrics, MH Ruz
Uzbekistan
Uzbekistan
PhD
Tashkent
N. K. Valievа
Republican Specialized Scientific and Practical Medical Center of Pediatrics, MH Ruz
Uzbekistan
Uzbekistan
PhD
Tashkent
N. A. Ikramova
Republican Specialized Scientific and Practical Medical Center of Pediatrics, MH Ruz
Uzbekistan
Uzbekistan
Tashkent
H. M. Kadyrhodzhaevа
Republican Specialized Scientific and Practical Medical Center of Pediatrics, MH Ruz
Uzbekistan
Uzbekistan
Tashkent
A. Kh. Akhmedovа
Republican Specialized Scientific and Practical Medical Center of Pediatrics, MH Ruz
Uzbekistan
Uzbekistan
PhD
Tashkent
References
1. Goncharova I.A., Beloborodova E.V, Freidin M.B. et al. Genetic factors of susceptibility to chronic viral hepatitis and liver fibrosis. Molekulyarnaya Biologiya=Molecular Biology. 2008. 42(2): 238—241. (In Russ.)
2. Romanov A.O., Belyaeva T.V, Esaulenko E.V The importance of innate immunity factors in the development of liver cirrhosis in patients with chronic HCV infection. Infektsionnyye Bolezni=Infectious Diseases. 2010. 11:548—553. (In Russ.)
3. Uchaikin V.F., Cherednichenko T.V., Smirnov A.V. Infectious hepatology. Moscow: GEOTAR-Media, 2012: 640. (In Russ.)
4. Bertoletti A., Ferrari C. Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection. Gut 2012; 61:1 754—1764.
5. Buchbinder E.I., Desai A. CTLA-4 and PD-1 Pathways: Similarities, Differences, and Implications of Their Inhibition. Am J Clin Oncol. 2016; 39(1):98—106.
6. Chan S.L., Wong VW, Qin S., Chan H.L. Infection and cancer: the case of hepatitis B. J Clin Oncol. 2016; 34:83—90.
7. Yang H.,Yeh S., Chen P., et al. Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma. J Natl Cancer Inst. 2008; 100:1134—43.
8. Chaouali M., Carvalho A. , Tezeghdenti A., et al. Cytotoxic T lymphocyte antigen-4 gene polymorphisms and susceptibility to type 1 autoimmune hepatitis in the Tunisian population. Genes & Diseases. 2018; 5:256—262.
9. Enciso-Vargas M., Ruiz-Madrigal B., Hernandez-Nazara Z., et al. Single Nucleotide Polymorphisms of Cytotoxic T-lymphocyte Antigen 4 (CTLA-4) and Susceptibility to Chronic Viral Hepatitis B and C Infections. Journal of Renal and Hepatic Disorders, 2018; 2(1): 10—17.
10. Kouki T., Gardine C.A., Yanagawa T., Degroot LJ. Relation of three polymorphisms of the CTLA-4 gene in patients with Graves'disease J. Endocrinol. Invest. 2002. 25(3):208—213.
11. 1. Jarnicki AG, Lysaght J, Todryk S, et al. Suppression of antitumor immunity by IL-10 and TGF-beta-producing T cells infiltrating the growing tumor: influence of tumor environment on the induction of CD4+ and CD8+ regulatory T cells. J Immunol. 2006; 177(2): 896—904.
12. EASL Clinical Practice Guidelines. Management of chronic hepatitis B virus infection. J Hepatol. 2017; 67:370—398.
13. Wang K, Zhu Q, Lu Y, et al. CTLA-4 +49 G/A Polymorphism Confers Autoimmune Disease Risk: An Updated Meta-Analysis. Genet Test Mol Biomarkers. 2017; 21(4):222—7. doi: 10.1089/gtmb.2016.0335.
14. Chen M., Chang Y, Tang F, et al. Influence of cytotoxic T lymphocyte-associated antigen 4 polymorphisms on the outcomes of hepatitis B virus infection. Molecular Мedicine Reports. 2014; 9: 645—652.
Review
For citations:
Inoyatova F.I., Inogamova G.Z., Abdullaevа F.G., Valievа N.K., Ikramova N.A., Kadyrhodzhaevа H.M., Akhmedovа A.Kh. Polymorphisms rs231775 and rs5742909 CTLA-4 gene and their associative relations with chronic HBV infection in children. CHILDREN INFECTIONS. 2020;19(3):15-18. (In Russ.) https://doi.org/10.22627/2072-8107-2020-19-3-15-18
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