CHOLESTASIS IN ACUTE AND CHRONIC VIRAL HEPATITIS
https://doi.org/10.22627/2072-8107-2014-13-3-51-53
Abstract
We observed 43 patients with cholestasis (21 — with acute viral hepatitis A and B and 22 — with chronic viral hepatitis B and C). Etiological diagnosis was based on the identification of specific markers of the spectrum. These 43 patients in addition to basic therapy ursodeoxycholic acid as a drug Ursosan of company «PRO.MED.CS Praha a.s.» (CzechRepublic). The control group consisted of 17 patients with acute viral hepatitis. Clinical signs are jaundice and itching of the skin, abdominal pain, significant hepatomegaly. Serum bilirubin level rises due to the conjugated fraction, alkaline phosphatase, gamma-glutamyltranspeptidase. When ultrasound revealed dilated bile ducts in the liver parenchyma, reactive edema of the gallbladder wall, signs gipomotornoy dyskinesia. Appointment ursosan in acute and chronic viral hepatitis occurring with cholestasis leads to the clinical and biochemical effects, and has a beneficial effect on the state of the liver and gall bladder.
About the Authors
V. F. Uchaikin
Russian National Research Medical University after N.I. Pirogov, Moscow
Russian Federation
Russian Federation
O. V. Molochkova
Russian National Research Medical University after N.I. Pirogov, Moscow
Russian Federation
Molochkova Oksana — CMS, Associate Professor, Department of Infectious Diseases in Children of Russian National Research Medical University after N.I. Pirogov Russian Ministry of Health; Shmitovskiy proezd, 29, CMCH №9, Moscow, 123317, Russia; (499) 256-60-26; ci-journal@mail.ru
Russian Federation
Molochkova Oksana — CMS, Associate Professor, Department of Infectious Diseases in Children of Russian National Research Medical University after N.I. Pirogov Russian Ministry of Health; Shmitovskiy proezd, 29, CMCH №9, Moscow, 123317, Russia; (499) 256-60-26; ci-journal@mail.ru
A. G. Pisarev
Russian National Research Medical University after N.I. Pirogov, Moscow
Russian Federation
Russian Federation
T. V. Cherednychenko
Russian National Research Medical University after N.I. Pirogov, Moscow
Russian Federation
Russian Federation
G. V. Chaplygina
Russian National Research Medical University after N.I. Pirogov, Moscow
Russian Federation
Russian Federation
References
1. Sherlok Sh. Duli. Zabolevaniya pecheni i zhelchnyih putey [Diseases of the Liver and Biliary Tract]. — M.: GEOTAR-Media, 1999. — 415 s. (In Russ).
2. Uchaykin V.F., Cherednichenko T.V., Smirnov A.V. Infektsionnaya gepatologiya: rukovodstvo dlya vrachey [ Infectious Hepatology: a Guide for Physicians]. — M.: GEOTAR-Media, 2012. — 640 s. (In Russ).
3. Lechenie Ursosanom holestaza pri ostryih i hronicheskih virusnyih gepatitah u detey [Treatment Ursosanom cholestasis in acute and chronic viral hepatitis in children] / G.V. Vyistavkina, A.G. Pisarev, V.F. Uchaykin, G.V. Chaplyigina // Detskie Infektsii [Children infection]. — 2002. — №1. — S. 40—43. (In Russ).
4. Singh J., Arora A., Garg P.K. Antituberculosis treatment-induced hepatotoxicity: role of predictive factors // Postgrad. Med. J. — 1995. — V. 71 (836) — P. 359—362.
5. Dmitrieva E.V. Rol apoptoza v patogeneze zabolevaniy pecheni razlichnoy etiologii [Role of apoptosis in the pathogenesis of liver diseases of different etiologies]: Avtoref. Diss. … d.m.n. — M., 2003. (In Russ).
6. Reyzis A.R. Apoptoz i antiapoptoticheskaya terapiya pri hronicheskih gepatitah B i C [Apoptosis and antiapoptotic therapy in chronic hepatitis B and C ] / A R. Reyzis, N.V. Matanina, D.A. Shmarov // Detskie Infektsii [Children infection]. — 2006. — T. 5, №4. — S. 11—14. (In Russ)
Review
For citations:
Uchaikin V.F., Molochkova O.V., Pisarev A.G., Cherednychenko T.V., Chaplygina G.V. CHOLESTASIS IN ACUTE AND CHRONIC VIRAL HEPATITIS. CHILDREN INFECTIONS. 2014;13(3):51-53. (In Russ.) https://doi.org/10.22627/2072-8107-2014-13-3-51-53
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