The frequency of detection of markers of Сytomegalovirus infection in children with recurrent respiratory diseases in patients with Shiga-toxin-associated hemolytic-uremic syndrome (STEC-HUS)
https://doi.org/10.22627/2072-8107-2021-20-1-12-18
Abstract
The paper presents data on the detection and role of cytomegalovirus infection (CMVI) in 146 children of certain groups aged from 3 months to 15 years who were hospitalized — frequently ill children with respiratory pathology, patients with shiga-toxin-associated hemolytic uremic syndrome (STEC-HUS) and schoolchildren with somatic diseases during rehabilitation in a sanatorium.
The aim of the study was to determine the frequency of detection of CMVI in the presented groups, the originality of the main clinical manifestations in correlation with the markers of activity of herpesvirus type V infection. Clinical monitoring was carried out, oropharyngeal swabs, saliva,blood samples (serum and blood cells) were studied using a set of laboratory diagnostic methods:RCM (rapid culture method) on Vero- and M-19 cells, IIR (reaction of indirect immunofluorescence), ELISA to detect specific antigens and antibodies (IgM, IgG).
The detection rate of CMV IgG in diagnostic values ranged from 6.4% in the group of frequently ill children with respiratory pathology to 31.7% in schoolchildren of the sanatorium, the acute course of infection was detected in3.2% and 6.4%, respectively, based on markers of acute infection (CMV IgM and cytomegalovirus antigen). In patients with STEC-HUS CMV IgG in diagnostic titers were recorded with the highest frequency — in 74.4% of patients.
About the Authors
I. B. Repina
Moscow Regional Research and Clinical Institute (MONIKI)
Russian Federation
Russian Federation
Irina Repina - PhD, Associate Professor of the course of children´s infections diseases
L. V. Feklisova
Moscow Regional Research and Clinical Institute (MONIKI)
Russian Federation
Russian Federation
Ludmila Feklisova - MD, Professor, Professor of the course of children´s infections diseases
M. K. Khadisova
Moscow Regional Research and Clinical Institute (MONIKI)
Russian Federation
Russian Federation
Marima Khadisova - PhD, Research Associate Childrens infections Disease Department
N. V. Karazhas
2N.F. Gamalei National Research Centre of Epidemiology and Microbiology Ministry of Russia
Russian Federation
Russian Federation
Natalia Karazhas - MD, Professor, The Head of the Laboratory of epidemiology of opportunistic infections
E. I. Likhanskaya
G.N. Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology of Rospotrebnadzor of the Russian Federation
Russian Federation
Russian Federation
Elena Likhanskaya - PhD, Head of the Laboratory
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Review
For citations:
Repina I.B., Feklisova L.V., Khadisova M.K., Karazhas N.V., Likhanskaya E.I. The frequency of detection of markers of Сytomegalovirus infection in children with recurrent respiratory diseases in patients with Shiga-toxin-associated hemolytic-uremic syndrome (STEC-HUS). CHILDREN INFECTIONS. 2021;20(1):12-18. (In Russ.) https://doi.org/10.22627/2072-8107-2021-20-1-12-18
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