The article presents the results of studies of the effectiveness and safety of domestic antiviral drug Аrbidol in children.

The article presents the results of the study of clinical and epidemiological data from 2044 children aged under 18 years who were hospitalized with influenza and other ARVI in the epidemic season 2010/11. The effectiveness of conducted antiviral therapy was also evaluated. The most frequently prescribed antiviral drug at prehospital and hospital stages was Arbidol. It is shown that early appointment of Arbidol significantly reduced the duration of the main symptoms of influenza and acute respiratory viral infections, and the risk of complications. 

Thearticle presents the results of years of studies (including biochemical and immunological) of the effectiveness of application and prophylaxis (in relation to nosocomial infections) and the safety of antiviral chemical preparation Arbidol in 694 children with influenza and influenza-like illness, including the coronavirus infection (43 children) and combined lesions of respiratory tract (150), indicating the possible inclusion of the drug in the complex therapy for children with the listed diseases, regardless of the severity and nature of their course. The studies were conducted according to the regulated standard of test conditions and randomized clinical trials.

The authors estimated epidemiological effectiveness of the program for prophylaxis of influenza and ARVI «Antigripp» for children of 7—12 years old. Children received Arbidol (capsules of 100 mg 2 times a week for 3 weeks) and Complivit activ. As a result there was a decline in absolute and relative indicators of ARVI morbidity risks. Epidemiological effectiveness of the program during the application of the drugs made up 56% and index of preventive efficacy was 2,3.

We described the results of Arbidol application for ARD prevention and treatment. It is proved that application of Arbidol in the period before the growth of influenza and other ARD morbidity helped to decrease the number of cases of morbidity among sickly children and children with pathology of upper and lower respiratory ways. Therapy with Arbidol decreases fever duration, intoxications and shortens periods of catarrhal inflammation in children with ARD.

We examined 40 sickly children with recurrent croup (RC — 28) and bronchial obstruction (ROB — 8), (RC + ROB — 4) aged from 18 months till 14 years. We found that high frequency of persistent herpes viruses usually occurs as associations with CMV, EBV and human herpes virus 6 type. We substantiated anti viral and immune corrective therapy in two schemes compared in efficacy: the 1st group was administered monotherapy with Viferon, and the 2nd group received combined therapy Viferon + Arbidol in doses according to the age during three months. We received a more expressed clinical immunologic effect from the therapy with decreased antigenic load and frequency of recurrence of RC and ROB with Viferon application in suppositories in combination with Arbidol per orally in the intermittent scheme during three months. 

We observed 70 patients: 40 patients with rotavirus infection and 30 patients with viral-bacterial intestinal co-infection. The age of the patient varied between 2 and 10 years. It was found that introduction of Arbidol in doses that correspond the patients’ age in 5-day course of complex therapy reliably reduces the duration of acute period of the disease: at rotavirus monoinfection (p < 0,001) and at viral and bacterial (p < 0,05). The time of elimination of rotavirus from patients’ stool also reduced significantly. In the group of patients who received the treatment with Arbidol, there was a clear tendency towards normalization of the quantitative content (CFU/g) of normal flora of the intestine, but only some of its representatives — lactobacilli and enterococci. 

The article presents the clinical and laboratory features of the course of rotavirus and norovirus infections in children. We provide the clinical and laboratory rationale for application of antiviral drugs in children of 3 to7 years old at moderate to severe forms of viral diarrhea. We determined the effect of Arbidol on elimination of rotavirus in the acute period disease.

152 cases of enteroviral meningitis in children aged 3 to 17 years were analyzed. All the patients were treated in the Municipal Health Care Institution «Clinical Hospital for Infectious Diseases No1» in Yaroslavl. The predominance of moderate forms of the disease with hypertensive syndrome was determined. An imbalance of the cytokine profile in the acute phase of the disease was registered. This was due to the increased production of pro-inflammatory cytokines and a decrease of protective role of anti-inflammatory cytokines. Despite relatively favorable course, there remained a high risk of formation of functional and organic disorders on the part of the nervous system in the period of convalescence, which creates ground for review and amendment of the standard protocols of treatment programs and including preparations of etiotropic direction. The authors tested therapeutic schemes and defined clinical and immunological efficacy of antiviral drugs Amixin and Arbidol with antiviral and interferonogenic effects as a part of complex basic therapy for enteroviral meningitis in children. In addition, the authors analyzed the results of follow-monitoring of 87 convalescents 3 months after their discharge from hospital. The results confirm the necessity and appropriateness of inclusion of preparations of etiotropic direction, in particular the antiviral preparations Arbidol and Amixin in standards of basic therapy of enteroviral meningitis in children.