Оп the analysis of 257 maps of children with influenza A and B at the age of 2 months — 1 7 years, two groups were distinguished: 1 group — 90 people of the 201 6/1 7 season; 2 group — 167 people of the 2017/18 season.

In the 201 6/1 7 season influenza A dominated (93.3%, n = 84) compared with influenza B (6.7%, n = 6) (p < 0,05). 2017/18 was characterized by the detection of influenza A in 68.9% (n = 115) of patients and B in 31.1% (n = 52) (p < 0,05). Along with the late onset of an epidemic rise in the incidence of influenza in 2 group, the 2017/18 season was characterized by the simultaneous circulation of influenza A and B, while in 1 group there was a sequential change of influenza A to B. Patients with influenza up to 2 years prevailed in 1 group (25.6%) compared with 2 group — 1 2.6% (p < 0,05). In the 2017/18 season more often patients were hospitalized 2—5 years old (40.1%, n = 67 vs 33.3%, n = 30) and 6—1 0 years old (29.9%, n = 50 vs 1 5.5%, n = 14) (p < 0,05). In 2 group the majority of those hospitalized were 2—3 and 6—7 years old (23.9% and 1 8.6% respectively). In both seasons the influenza had typical clinical symptoms, but in 2 group 7.7% had hemorrhagic and myalgic syndromes, which was not observed in 1 group. In the blood of patients of 2 group leukopenia prevailed at all ages: up to 1 year 55.5%, 1—5 years old — 43%, 6—10 years old — 52.5%, older than 1 2 years old — 1 0% compared with patients of 1 group (p < 0,05). Lymphocytosis in normocytosis was detected in children over 1 2 years old (82%). In 2 group compared with 1 group thrombocytopenia was more frequently detected at all ages: 50.3% (n = 84) versus 14.4% (n = 13) (p < 0,05).

Human herpes virus type 6 (HHV-6) is the etiological agent of plenty diseases. The form of the developing pathology depends on the localization of the virus in T-lymphocytes and on virus type: HHV-6A or HHV-6B, but identification of the type is possible by nucleotide sequence only. In Russia, researching on the typing of HHV-6 are conducted in Moscow and St. Petersburg mainly, but results is discordant. Also the prevalence of HHV-6A and HHV-6B among various population groups is of particular interest.

Objective: to study the status of markers of the transport system of iron metabolism and the marker profile of HBV infection, depending on the degree of iron overload syndrome in children with chronic hepatitis B.

The object of the study were 1 85 children with HBV with iron overload syndrome, aged 4—18 years. Specific research methods included determination by ELISA: sTfR (soluble transferrin receptors), FR (ferritin), FPN (ferroportin), HEPH (hefestin), TfR-2 (transferrin-2 receptors) and serum active Hepcidin-25 (HPS) blood. Viro-logical verification was performed by ELISA and PCR: HBsAg, HBsAb, HBeAg, HBeAb, total HBcorAb, HCVAb, HDVAb, HBV-DNA.

A directly proportional dependence of the FPN level and an inversely proportional dependence of the level of HEPH/TfR-2 on the degree of iron overload syndrome were revealed — the higher the presentability of hemosiderosis, the higher the expression of FPN and the suppression of HEPH/TfR-2 with the consequence of decreased transcription of hepcidin-25 in hepatocytes. Confirmation of this fact served as the severity of HBV activity, which correlated with the degree of iron overload syndrome, the lower the transferrin saturation ratio, the higher the viral aggression, which we interpreted as an unfavorable factor in terms of the prognosis of the disease.

The article presents current information about the etiology, epidemiology, clinical manifestations of parvovirus infection in children. The problems of the use of laboratory tests, treatment and prevention ofinfection.

The review of the scientific literature presents current data on vitamin D in children with infections (acute respiratory diseases, pneumonia, otitis, staphylococcal infections of the skin and nasopharynx, sepsis, and others). Studies on the adverse effects of hypovitaminosis D in children on recovery from infections are given. The positive effects of vitamin D incorporation in standard infection therapy in children have been noted.

The urgency of the problem is due to the fact that respiratory diseases occupy one of the first places in the structure of child morbidity, and community-acquired pneumonia remains one of the main causes of hospitalization and mortality among children. Streptococcus pneumonia remains the leading bacterial etiological agent of community-acquired pneumonia in the total population of pathogens.

The article presents a statistical study of the impact of vaccination against pneumococcus on the incidence of community-acquired pneumonia in children in Penza, Russia. It was revealed that the incidence of community-acquired pneumonia in children vaccinated with 1 3-valent conjugate pneumococcal vaccine is 3.2 times lower than in unvaccinated children.

A clinical study was conducted to evaluate the effectiveness of Adiarin ^Ыте tannatе) in infants and young children with acute intestinal infections (AII) of various etiologies. As a result of the study, reliable positive dynamics of the main clinical symptoms of acute intestinal infections (reduction of the duration of diarrhea, normalization of stool frequency and nature) were established when the drug Adiarin ^Ыте tannatе) was used in the acute period of the disease, which indicates its effectiveness.

Justify the need to include two medicinal forms of recombinant interferon α -2b in combination with highly active antioxidants vitamins E and C (VIFERON®) in the form of rectal suppositories and gel for external use in the treatment of infectious mononucleosis in children.

A clinical and laboratory examination of 115 children with infectious mononucleosis aged 3 to 11 years was carried out. Depending on the treatment, the patients were divided into three groups: the first group consisted of 50 children who received combination therapy with recombinant interferon α -2b (rIFN- α -2b, VIFERON®) in the acute period of the disease in the form of rectal suppositories and a gel for external use . The second group of children (35 people) received only rIFN- α -2b in the acute period of the disease in the form of rectal suppositories. The comparison group (III) was 30 people who received only pathogenetic and symptomatic therapy in the acute period of the disease.

Combined therapy with recombinant interferon α -2b in combination with highly active antioxidants, vitamins E and C (VIFERON®), as rectal suppositories and gel for external use, significantly improved the clinical and laboratory manifestations of the disease and shortened the duration of stay in a hospital not only with group of comparison, but also with patients of group II who received recombinant interferon α -2b (VIFERON®) only in the form of rectal suppositories.

The conclusion. The combined use of recombinant interferon α -2b (VIFERON®) in the form of rectal suppositories and gel for external use may be recommended for the treatment of infectious mononucleosis in children.

We generalized the observed results obtained in the last twenty years from patients at the age of 1 to 14 years suffered from acute erythematous ixodic tick-borne borreliosis. Clinical characteristics of erythematous ixodic tick-borne borreliosis have not changed dramatically over twenty years. Key manifestations in children remain erythema at the site of a tick bite, fever, and regional lymphadenitis. These signs allow us to diagnose nosological form of the disease.

The prognosis for cholera in the world remains unfavorable. There is a high incidence of cholera in the countries of Africa and the Caribbean, which does not exclude the possibility of importation of the infection to Russia and the recurrence of the cholera epidemic.

The aim of the study was to establish the clinical and epidemiological characteristics of cholera Eltor in the Astrakhan region in 1970.

A retrospective study the information sources were the medical history and results of laboratory examination of 1 246 patients with cholera in 1970 treated in the Regional infectious hospital and redeveloped during the epidemic hospitals of Astrakhan.

The duration of a cholera epidemic on the territory of Astrakhan region, with mass cases of the disease, accounted for 55.0 ± 15.8 days. The infection rate of cholera of inhabitants of Astrakhan were lower compared to living in rural areas. Water infected with Cholera Vibrio was the main factor of pathogen transmission. The predominant clinical forms of cholera were mild and moderate (72%), the proportion of severe and algid forms was 28% of the total number of patients.

The maximum development of cholera epidemic reached in the delta areas of Astrakhan region. The factor of the pathogen transmission was water, which contributed to the rapid increase in the number of patients. With a total number of severe and algid forms of cholera 350 (28%), in 35 (10%) patients, the disease was fatal.

This article will discuss the criteria for assessing the severity of the complication of infectious mononucleosis at children. The method for determining the degree of severity of the disease using a point — based assessment for each clinical symptom and the results of standard laboratory studies is proposed. The method allows on the day of treatment to clarify the severity of infectious mononucleosis and choose the tactics of patient management.

In recent years, there has been an increase in bacterial strains capable of synthesizing extended-spectrum β-lactamase (ESBL).

The study examined the ability of K. pneumoniae strains isolated from 30 patients in the surgical ward with urinary tract infections (1 8), from the areas of surgical intervention (7) and nosocomial pneumonia (5). Synthesis of ESBL K. pneumoniae was detected by means of a phenotypic test and using two disks.

The ESBL-positive K. pneumoniae was found in 40% of the isolated nosocomial strains. It was established that ESBL-positive strains of K. pneumoniae were significantly more often (p <0.05) isolated from infections in the area of surgical intervention and pneumonia (86% and 60%, respectively).

The paper presents a clinical case of recurrent parotitis in a girl of 8 years during differential diagnosis, classified as Sjogren's syndrome in combination with autoimmune thyroiditis.

December 12—14, 2018, Moscow