Clinical case of drug reaction with eosinophilia and systemic symptoms in response to doxycycline usage in adolescent

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is rare type of hypersensitivity that could lead to multiple organ dysfunction syndrome. First line of treatment is fast causal drug identification and its withdrawal and systemic glucocorticoids. A clinical case of a DRESS-syndrome in 16-years-old adolescent with rush, fever, lymphadenopathy and hepatitis manifested in response to doxycycline usage for acne treatment is presented. To diagnosis, the patient was validated according to the three most used criteria systems: Bocquet H. et al., European Registry of Severe Cutaneous Adverse Reactions (RegiSCAR) and Japanese consensus group («J-Scar»).

The purpose of this clinical observation was to familiarize readers with this rare complication, the criteria systems used in its diagnosis. 

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