Mumps infection in children at the present stage
https://doi.org/10.22627/2072-8107-2026-25-2-39-41
Abstract
Purpose: to conduct a comparative assessment of modern methods for diagnosing mumps infection.
Materials and methods: The study was conducted on samples of biomaterial taken from 16 children aged 4 to 17 years, who were undergoing treatment at the State Budgetary Institution of the Republic of Dagestan «Republican Center for Infectious Diseases, Prevention and Control of AIDS named after S.M. Magomedov», Makhachkala. Patients were admitted to the hospital between May 23 and June 7, 2024. Samples of biomaterial were taken upon admission and during treatment. Specific antibodies IgM and IgG to the mumps virus were determined in the blood using enzyme-linked immunosorbent assay (ELISA), viral RNA was detected in oropharyngeal swabs using polymerase chain reaction (PCR) and loop-mediated isothermal amplification (LAMP).
Results: in all patients, the diagnosis of «mumps» was established on the basis of a serological test (ELISA IgM + ). At the same time, IgG antibodies were not detected in any of the children during their hospital stay. Using the PCR method, mumps virus RNA was detected in all smear samples from the oropharyngeal mucosa both upon admission and during their hospital stay. Using the LAMP method, mumps virus RNA was detected in all children on the 1—2 day of illness, in 13 out of 16 children (81.25% of cases) on the 3—13 day of illness. Thus, it should be noted that molecular methods are appropriate to use for diagnosing mumps in children at the present stage.
About the Authors
T. L. Zamotaeva
Federal Budgetary Scientific Institution Central Research Institute of Epidemiology of Rospotrebnadzor
Russian Federation
Russian Federation
Moscow
E. A. Cherkashin
Federal Budgetary Scientific Institution Central Research Institute of Epidemiology of Rospotrebnadzor
Russian Federation
Russian Federation
Moscow
M. A. Ninalalov
S.M. Magomedov Republican Center for Infectious Diseases, AIDS Prevention and Control
Russian Federation
Russian Federation
Makhachkala
Zh. B. Ponezheva
Federal Budgetary Scientific Institution Central Research Institute of Epidemiology of Rospotrebnadzor
Russian Federation
Russian Federation
Moscow
V. G. Akimkin
Federal Budgetary Scientific Institution Central Research Institute of Epidemiology of Rospotrebnadzor
Russian Federation
Russian Federation
Moscow
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Review
For citations:
Zamotaeva T.L., Cherkashin E.A., Ninalalov M.A., Ponezheva Zh.B., Akimkin V.G. Mumps infection in children at the present stage. CHILDREN INFECTIONS. 2026;25(2):39-41. (In Russ.) https://doi.org/10.22627/2072-8107-2026-25-2-39-41
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