EPIDEMIOLOGICAL PATTERNS OF CHRONIC HBV-INFECTION IN FAMILY CASES
https://doi.org/10.22627/2072-8107-2016-15-3-62-66
Abstract
Analysis and examination of 220 families allowed to reveal the presence of interfamily concentration of chronic HBV-infection in 30.9% cases. The role of interdependence of the different haptoglobin (HP) phenotypes with the genotypic properties of the virus in the formation of «family cases» of chronic hepatitis В (CHB) were defined and the peculiarities of the profile of HBV markers depending on the carrier and HP viral genotype in children from family cases with CHB were discovered.
About the Authors
F. I. Inoyatova
The Republic Special Scientific-Practical Medical Center of Pediatrics of the Republic of Uzbekistan, Tashkent
Uzbekistan
Uzbekistan
Inoyatova Flora — M.D., Professor, Head of Hepatology Department.
3 Talаnt, 2 Chimbay Street, Tashkent, 100179, Uzbekistan; phone (99871) 229-38-75; hepar.child@yandex.ru
F. G. Abdullaeva
The Republic Special Scientific-Practical Medical Center of Pediatrics of the Republic of Uzbekistan, Tashkent
Uzbekistan
Uzbekistan
G. Z. Inogamova
The Republic Special Scientific-Practical Medical Center of Pediatrics of the Republic of Uzbekistan, Tashkent
Uzbekistan
Uzbekistan
References
1. Aprosina Z.G., Serov V.V. [The pathogenesis of chronic hepatitis B] // Archive Pathol. 2001 №1. P. 58—61. (In Russ.)
2. Ivashkin V.T., Herman E.N., Maevskaya M.V. [Latent infection with hepatitis B] // Russian Journal of Gastroenterology Hepatology and Coloproctology. 2008. №2. P. 4—11. (In Russ.)
3. Inoyatovа F.I. [Chronic viral hepatitis in children]. — Tashkent: Publishing. honey. Litas. them. Abu Ali ibn Sina, 1997. — 274p. (In Russ.)
4. Yakovlev A.A., Komarov A.Ya., Musatov V.B. at al. [Chronic viral hepatitis and their outcomes: what awaits us in the next decade] // Klin. perspektivy gastroenterol, gepatol. 2015. №2. P.13—21. (In Russ.)
5. Usmanov M.K., Musabaev E.I. [Epidemiological zakonomernsti circulation HB virus infection in the foci of chronic viral hepatitis B] //Pathology. 2002. № 1. P. 92—94. (In Russ.)
6. Rakhimov R.A., Khodzhaev Sh.Kh. [HB-virus infection in the family center and the conditions of its transmission] // Med. Zh. Uzb. 1986. №2. P. 33—34. (In Russ.)
7. Shakhgildyan D.I., Mikhailov M.I., Huhlovich M.I. [Modern epidemiological characteristics of hepatitis B] // Attending Vrach. 2002. №6. P. 16—19. (In Russ.)
8. Effect of genotype and phenotype properties of hepatitis B virus in the course of chronic hepatitis] // Hepatology. 2005. №3. P.4—10. (In Russ.)
9. Idrisovа L.R. [Epidemiological features, mechanisms of development and clinical significance of HBsAg-negative hepatitis B] // Viral Hepatitis: Advances and Perspektivy. 2005. №3. P.12—16. (In Russ.)
10. Lopez J.L., Mbayed V.A., Telenta P.F.S. et al. [HBe-minus mutants of hepatitis virus. Molecular characterization and relation to viral genotypes] // Virus Reseach. 2002. Vol.87. P.41—49.
11. Chia-Ming Chu, Chau-Ting Yen, Ching-Song Lee et al. Precore stop mutant in Hbe Ag-positive patients with chronic hepatitis B: clinical characteristics and correlation with the course of HBeAgAnti-HBe seroconversion // J. Clin. Microbiol. 2002. Vol. 40, №1. P. 16—21.
Review
For citations:
Inoyatova F.I., Abdullaeva F.G., Inogamova G.Z. EPIDEMIOLOGICAL PATTERNS OF CHRONIC HBV-INFECTION IN FAMILY CASES. CHILDREN INFECTIONS. 2016;15(3):62-66. (In Russ.) https://doi.org/10.22627/2072-8107-2016-15-3-62-66
Views:
973
Email this article 