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MODERN ASPECTS OF DIAGNOSTICS, TREATMENT AND PREVENTION OF CONGENITAL TOXOPLASMOSIS

https://doi.org/10.22627/2072-8107-2017-16-2-45-49

Abstract

Diagnostics of intrauterine infection associated with T. gondii, today is a task with an ambiguous solution for different specialists — gynecologists, obstetricians, neonatologists, infectious disease specialists, resuscitators. This problem is interdisciplinary, and its coordinated decision, diagnosis and treatment of this disease at an early stage will reduce the risk of stillbirths, deaths and severe consequences. The article reflects the current literature data on the clinical features of toxoplasmosis in relation to the genotype of Toxoplasmа, circulating in the world. Particular importance is given to the selection of methods for prenatal and postnatal diagnosis of toxoplasmosis. The data of the latest review (2017) of theAmericanAcademy of Pediatrics on the diagnosis, treatment and prevention of congenital toxoplasmosis are presented. The main clinical manifestations of toxoplasmosis were revealed. Basic preparations for treatment of toxoplasmosis is Trimethoprim + sulfamethoxazole (Biseptol) and spiramycin (Rovamycin).

About the Authors

M. S. Savenkova
Russian National Research Medical University after N.I. Pirogov; Scientific and Practical Center for helping children after V.F. Voino-Yasenetsky
Russian Federation
Marina S. Savenkova, MD, professor of the Department of Clinical Functional Diagnostics of Russian National Research Medical University after N.I. Pirogov, Moscow


G. M. Balakireva
Scientific and Practical Center for helping children after V.F. Voino-Yasenetsky
Russian Federation
Moscow


Yu. L. Ishutina
Scientific and Practical Center for helping children after V.F. Voino-Yasenetsky
Russian Federation
Moscow


M. P. Shalatonin
Morozovskaya Children's City Clinical Hospital
Russian Federation
Moscow


References

1. Дзуцева Ф.К., Никитина Г.Ю., Борисенко Ю.В., Иванова Л.П. Клиника и лечение токсоплазмоза. Лечащий врач. 2008;10: 51—55. [Dzutseva F.K., Nikitina G.Yu., Borisenko Yu.V., Ivanova L.P. A clinic and treatment of toxoplasmosis. Treating Doctor. 2008;10: 51—55. (In Russ.)].

2. Кузнецова Т.В., Ленская Н.Г., Утешев Д.Б. Токсоплазмоз. Лечебное дело. 2008; 4: 88—93. [Kuznetsova T.V., Lenskaya N.G., Uteshev D.B. Тoxoplasmosis. Lechebnoye Delo. 2008; 4: 88—93. (In Russ.)].

3. Su G., Khan A., Zhou P., D. Majumdara, D. Ajzenbergd, M.-L. Darded, X.-Q. Zhuf, J.W. Ajiokag, B.M. Rosenthalh, J.P. Dubeyh, L.D. Sibleyb. Globally diverse Toxoplasma gondii isolates comprise six major clades originating from a small number of distinct ancestral lineages. Proc Natl Acad Sci USA. 2012; 109 (15) : 5844—5849.

4. Sibley L.D., Khan A., Ajioka J.W., Rosenthal B.M. Genetic diversity of Toxoplasma gondii in animals and humans. Philos Trans R Soc Lond B Biol Sci. 2009; 364 (1530) : 2749—2761.

5. McLeod R., Boyer K.M., Lee D., Mui E., Wroblewski K., Karrison T., Noble A.G., Withers S., Swisher C.N., Heydemann P.T., Sautter M., Babiarz J., Rabiah P., Meier P., Grigg M.E. Prematurity and severity are associated with Toxoplasma gondii alleles (NCCCTS, 1981— 2009). Clin Infect Dis. 2012; 54 (11) : 1595—1605.

6. Авдеева М.Г., Кончакова А.А. Современное течение и особенности диагностики острого приобретенного токсоплазмоза. Инфекционные болезни, 2012; 10(3): 63—66. [Avdeeva M.G., Konchakova A.A. Modern flow features of diagnostics of the sharp purchased toxoplasmosis. Infections Diseases. 2012; 10(3): 63— 66. (In Russ.)].

7. Dubley J.P., Jones J.l. Toxoplasma gondii infection in humans and animals in the United States. Int J Parasitol. 2008 Sep; 38(11):1257—78.

8. Di Carlo P., Romano A., Schimmenti M.G., Mazzola A., Titone L. Matemofetal Toxoplasma gondii infection: critical review of available diagnostic methods. Infez Med. 2008;16(1): 28—32.

9. Сarter A.O., Frank J.W. Congenital toxoplasmosis: epidemiologic features and control. CMAJ .1986; 135(6): 618—23.

10. Messier V., Levesque B., Proulx J.F., Rochette L., Libman M.D., Ward B.J., Serhir B., Couillard M., Ogden N.H., Dewailly E., Hubert B., Dery S., Barthe C., Murphy D., Dixon B. Seroprevalence of Toxoplasma gondii amond Nunavik Inuit (Canada). Zoonoses Public Health. 2009 May; 56(4):188—97.

11. Беляева Н.М., Зембатова С.Х., Дзуцева Ф.К. Проблема токсоплазмоза у беременных и новорожденных. Материалы IV Ежегодного Всероссийского Конгресса по инфекционный болезням. 2012: 51. [Belyaeva N.M., Zembatova S.Kh., Dzutseva F.K. Problem of toxoplasmosis for pregnant and new-born. Materials of IV of Annual All-russian Congress for infectious to illnesses. 2012: 51. (In Russ.)].

12. Барычева Л.Ю., Голубева М.В., Кабулова М.А., Косторная И.В. Врожденный токсоплазмоз: клиническое течение и резидуальные исходы. Детские инфекции. 2014; 13(2): 52—57. [Barycheva L.Yu., Golubeva M.V., Kabulova M.A., Kostornaya I.V. Innate toxoplasmosis: clinical flow and резидуальные ends. Detskie Infekcii = Childrens Infections. 2014; 13(2): 52—57. (In Russ.)].

13. Пузырева Л.В., Балабохина М.В., Сафонов А.Д. Токсоплазмоз: современные представления, диагностика и профилактика. Дальневосточный журнал инфекционной патологии. 2016; 30:81—86. [Puzyreva L.V., Balabokhina M.V., Safonov A.D. Toksoplasmosis: modern concepts, diagnostics and prevention. Far Eastern Journal of Infectious Pathology. 2016; 30:81—86. (In Russ.)].

14. Stray-Pedersen B. Toxoplasmosis in pregnancy. Baillieres Clin Obstet Gynaecol. 1993; 7 (1): 197—37.

15. Токсоплазмоз во время беременности: профилактика, диагностика и лечение. Клиническое практическое руководство общества акушеров-гинекологов Канады, 2013. Журнал Эндокринология. 2013;1(9): 86—91. [Toxoplasmosis during pregnancy: prophylaxis, diagnostics and treatment. Clinical practical guidance of society of accoucheurs-gynaecologists of Canada, 2013. A magazine Endocrinology. 2013;1(9): 86—91. (In Russ.)].

16. Remington J.S., McLeod R., Thulliez P., Desmonts G. Toxoplasmosis. In: Remington J., Klein G., Wilson C., Baker C., eds. Infectious Disease of the Fetus and Newborn Infan, 6th ed. Philadelphia, PA: W.B. Saunders; 2010: 947—1091.

17. Maldonado Y.A., Read J.S., AAP COMMITTEE ON INFECTIOUS DISEASES. Diagnosis, Treatment, and Prevention of Congenital Toxoplasmosis in the United States. Pediatrics. 2017;139(2):e20163860.

18. Phan L., Kasza K., Jalbrzikowski J. et al. Toxoplasmosis Studi Group. Longitudinal study of new eye lesions in children with toxoplasmosis who were not treated during the first year of life. Am J Ophthalmol. 2008; 146(3):375—384.

19. McLeod R., Boyer K., Karrison T., Kasza K., Swisher C., Roizen N., Jalbrzikowski J., Remington J., Heydemann P., Noble A.G., Mets M., Holfels E., Withers S., Latkany P., Meier P. Outcome of treatment for congenital toxoplasmosis, 1981—2004: the National Collaborative Chigago-Based, Congenital Toxoplasmosis Study. Clin Infect Dis. 2006; 42(120): 1383—1394.

20. Montoya J.G. Laboratory diagnosis of Toxoplasma gondii infection and toxoplasmosis. J Infect Dis. 2002;185 (Suppl 1): 573—82.

21. Stray-Petersen B. Toxoplasmosis in pregnancy. Baillieres Clin Obstet Gynecol. 1993; 7(1) : 107—37.

22. Liesenfeld O., Press C., Montoya J.G., Gill R., Isaac-Renton J.L., Hedman K. et al. False-positive results in immunoglobulin M (IgM) toxoplasma antibody tests and importance of confirmatoty testing: the Platelia Toxo IgM test. J Clin Microbiol. 1997; 35(1):174—8.

23. Долгих Т.И. Токсоплазмоз: возвращение к проблеме. Спеквыпуск. "Лаборатория ЛПУ". 2014; 4: 57—60. [Dolgikh T.I. Toxoplasmosis: return to the problem. Special release. «Laboratory of health facilities». 2014; 4: 57—60. (In Russ.)].

24. Romand S., Wallon M., Franc J., Truilliez P., Peyron F., Dumon H. Prenatal diagnosis using polymerase chain reaction on amniotic fluid for congenital toxoplasmosis. Obstet Gynecol. 2001; 97:296— 300.

25. Wallon M., Liou C., Garner P., Peyron F. Congenital toxoplasmosis: systematic review of evidence of efficacy of treatment in pregnancy. BMJ.1999; 318(7197):1511—4.

26. Peyron F., Wallon M., Liou C., Garner P. Treatments for toxoplasmosis in pregnancy. Cochrane Database Syst Rev. 1999; Issue 3. Art. No.:CD001684. DOI: 10.1002/14651858.CDOO1684.

27. Montoya J.G., Remington J.S. Management of Toxoplasma gondii Infection during pregnancy. Clin Infect Dis. 2008; 47(4):554—66.


Review

For citations:


Savenkova M.S., Balakireva G.M., Ishutina Yu.L., Shalatonin M.P. MODERN ASPECTS OF DIAGNOSTICS, TREATMENT AND PREVENTION OF CONGENITAL TOXOPLASMOSIS. CHILDREN INFECTIONS. 2017;16(2):45-49. (In Russ.) https://doi.org/10.22627/2072-8107-2017-16-2-45-49

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