THE VALUE OF THE HERPES VIRUS TYPE 6 IN THE GENESIS OF SEIZURES IN CHILDREN
https://doi.org/10.22627/2072-8107-2014-13-4-18-23
Abstract
The value of human herpes virus type 6 (HHV-6) in the structure of seizures in 114 children in three groups of patients: with neuroinfections, with epilepsy and febrile convulsions was studied. Determination of HHV-6 by polymerase chain reaction in the acute period of the disease is a reliable sign (p < 0.001), and most often diagnosed in children in the group with febrile seizures (53.8%). Recovery in children with seizures caused by HHV-6, was observed only in 28% of cases,38.8% of patients in the outcome of the disease expand the epilepsy.
About the Authors
L. V. VashuraRussian Federation
M. S. Savenkova
Russian Federation
DMS, Professor, Russian National Research Medical University named after N. I. Pirogov; 117049, Moscow, 4th Dobryninsky per., 1); (499) 236-13-20
M. P. Savenkov
Russian Federation
M. Yu. Kalugina
Russian Federation
N. V. Karazhas
Russian Federation
T. N. Rybalkina
Russian Federation
I. R. Samsonovich
Russian Federation
References
1. Мurakami K. A study of the relationship between initial febrile seizures and human herpes virus 6, 7 infections. No To Hattatsu. — 2004; 36 (3): 248—252.
2. Karazhas N.V., Malyishev N.A., Ryibalkina T.N., Kalugina M.Yu., Boshyan R.E., Kisteneva L.B., Cheshik S.G. Gerpeticheskie infektsii.
3. Epidemiologiya, klinika, diagnostika, lechenie i profilaktika: Metodicheskie rekomendatsii. — Moskva, 2007. (In Russ.)
4. Kuskova T.K., Belova E.G. Semeystvo gerpesvirusov na sovremennom etape // Lechaschiy Vrach. — 2004. — №5. — S. 6—11. (In Russ.)
5. Melyohina E.V., Chugunova O.L., Karazhas N.V. Klinicheskie formyi infektsii, vyizvannoy virusom gerpesa cheloveka 6 tipa, u detey starshe odnogo goda // Pediatriya i Detskaya Hirurgiya: Tezisyi. — T. 3. — 2012. (In Russ.)
6. Abdel-Haq N.M., Asmar B.I. Human herpesvirus 6 (HHV6) infection // Indian J Pediatr. — 2004; 71 (1): 89—96.
7. Sarah S. Long, Larry K. Pickering, Charles G. Principles and practice of pediatric infectious diseases. Prober Churchill Livingstone Inc. — 1997. — Р. 1821.
8. Pereira C.M., Gasparetto P.F., Corrкa M.E., Costa F.F., de Almeida O.P., Barjas-Castro M.L. Human herpesvirus 6 in oral fluids from healthy individuals // Arch Oral Biol. — 2004; 49 (12): 1043—6.
9. Isakov V.A., Borisova V.V., Isakov D.V. Gerpes: patogenez i laboratornaya diagnostika: Rukovodstvo dlya vrachey. — SPb.: Lan, 1999. (In Russ.)
10. Kalugina M.Yu., Karazhas N.V., Ryibalkina T.N., Boshyan R.E., Ermakova T.M., Tebenkov A.V. Aktualnost diagnostiki infektsii, vyizvannoy virusom gerpesa cheloveka 6-go // Detskie Infektsii. — 2012. — №1. — S. 60—63. (In Russ.)
11. Protas I.I., Hmara M.E. Sovremennyie predstavleniya ob etiologii i patogeneze gerpeticheskoy infektsii tsentralnoy nervnoy sistemyi // Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. — 2002. — №2. — S. 73—75. (In Russ.)
12. Hmara M.E. Gerpeticheskaya infektsiya TsNS: klinikomorfologicheskie i patogeneticheskie aspektyi // Infektsii i Antimikrobnaya Terapiya. — 2005. — T. 07. — № 4. (In Russ.)
13. Yuschuk N.D. Porazheniya nervnoy sistemyi pri gerpeticheskih in-fektsiyah: uchebnoe posobie // N.D. Yuschuk, A.V. Stepanchenko, E.P. Dekonenko. — M.: Profil. — 2005. — 96 s. (In Russ.)
14. Sorokina M.N., Skripchenko N.V. Virusnyie entsefalityi i meningityi u detey: Rukovodstvo dlya vrachey. — M., 2004. — S. 192—201. (In Russ.)
15. Nikolskiy M.A., Radyish M.V. Rol virusov gerpesa cheloveka 6 i 7-go tipov v vozniknovenii febrilnyih sudorog u detey // Voprosyi Diagnostiki i Pediatrii. — 2012. — T 4. — №4; S. 46—48. (In Russ.)
16. Ward K.N., Andrews N. J., Verity C.M. et al. Human herpesvirus-6 and 7 each cause significant neurological morbidity in Britain and Ireland // Arch. Dis. Child. — 2005; 90 (6): 619—623.
17. Caserta M.T., McDermott M.P., Dewhurst S., Schnabel K., Carnahan J.A., Gilbert L., Lathan G., Lofthus G.K., Hall C.B. Human her-pesvirus 6 (HHV6) DNA persistence and reactivation in healthy children // J Pediatr. — 2004; 145 (4): 478—84.
Review
For citations:
Vashura L.V., Savenkova M.S., Savenkov M.P., Kalugina M.Yu., Karazhas N.V., Rybalkina T.N., Samsonovich I.R. THE VALUE OF THE HERPES VIRUS TYPE 6 IN THE GENESIS OF SEIZURES IN CHILDREN. CHILDREN INFECTIONS. 2014;13(4):18-23. (In Russ.) https://doi.org/10.22627/2072-8107-2014-13-4-18-23