PERSISTENT INFECTION IN FREQUENT AND PROLONGED ILL CHILDREN, POSSIBILITIES OF ETIOPATHOGENETIC THERAPY
https://doi.org/10.22627/2072-8107-2014-13-4-41-45
Abstract
We present the results of the etiologic diagnosis and therapy of 243 frequent and prolonged ill children aged from 1 to 17 years. Microbiological, serological and molecular biological methods for the determination of bacterial agents, respiratory chlamydia and mycoplasma, Epstein-Barr virus, human herpes virus type 6 and cytomegalovirus were used. The dominant role of the active persistence of herpesviruses was shown (87%); bacterial pathogens were identified rarely, mainly in association with herpesvirus. 96 patients received a medication of recombinant interferon D-2 (VIFERON) and then endogenic interferon inductor, 57 patients - recombinant interferon D-2 (VIFERON) in conjunction with antibiotic therapy and then bacterial lysates. Treatment of children depending on the diagnosed infections allowed to achieve stable normalization of state in 78% of cases.
About the Authors
A. S. Levina
Scientific and Research Institute of Children’s Infections, Sankt Petersburg
Russian Federation
CMS, Senior Researcher, Department of respiratory infections, Scientific and Research Institute of Children’s Infections, Russia, St. Petersburg, str. Professor Popov, 9
Russian Federation
CMS, Senior Researcher, Department of respiratory infections, Scientific and Research Institute of Children’s Infections, Russia, St. Petersburg, str. Professor Popov, 9
I. V. Babachenko
Scientific and Research Institute of Children’s Infections, Sankt Petersburg
Russian Federation
Russian Federation
References
1. Nesterova I.V. Problemy lecheniya virusno-bakterialnyh respiratornyh infekcii u «chasto i dlitelno boleiushchih» immunokompromiti rovannyh detei [The problem of treating viral and bacterial respiratory infections «often and long ill» immunocompromised children] // Pediatriya. — 2009. — №6. — S. 26—29. (In Russ).
2. Profilaktika gospitalnoi i povtornoi zabolevaemosti ORVI u chasto boleiushchih detey, prozhivaiushchih v usloviyah ekologicheskogo neblagopoluchiya [Prevention of hospital and re-incidence of acute respiratory viral infections in often ill children living in conditions of ecological trouble] / A.I. Aminova I dr. // Detskie Infektsii. — 2009. — №4. –S. 40—44. (In Russ).
3. Samsygina G.A. Chasto boleiushchiie deti: problemy patogeneza, diagnostiki i terapii [Often ill children: problems of pathogenesis, diagnosis and therapy] // Pediatriya. — 2004. — Т. 6, № 2. — S. 66—73. (In Russ).
4. Karlidag T. Presence of herpesviruses in adenoid tissues of children with adenoid hypertrophy and chronic adenoiditis / T. Karlidag, Y. Bulut, E. Keles // Kulak Burun Bogaz Ihtis Derg. — 2012. — V. 22 (1) — P. 32–37.
5. Herberhold S. Frequent Detection of Respiratory Viruses by Real-Time PCR in Adenoid Samples from Asymptomatic Children / S. Herberhold, A. Eis-Hubinger, M. Panning // J Clin Microbiol. — 2009. — V. 47 (8). — P. 2682–2683.
6. Nistico L. Adenoid Reservoir for Pathogenic Biofilm Bacteria / L. Nistico, R. Kreft, A. Gieseke et al. // J Clin Microbiol. — 2011. — V. 47 (4). — P.1411–1420.
7. Kushelevskaya O.V. Rol Chlamydia pneumoniae, Mycoplasma pneumoniae v razvitii infektsionnogo protsessa u detey s hronicheskimi zabolevaniyami legkih [The role of Chlamydia pneumoniae, Mycoplasma pneumoniae in the development of infection in children with chronic lung disease] / O.V. Kushelevskaya, Т.B. Sentsova, I.K. Volkov // Voprosy Sovremennoy Pediatrii. — 2007. — Т.6, №2. — S. 148—149. (In Russ).
8. Melnik O.V. Rol virusa Epshteina-Barr i tsitomegalovirusa v porazhenii respiratornogo trakta chaste boleiushchih detey [The role of the Epstein-Barr virus and cytomegalovirus in the defeat of the respiratory tract in often ill children] / O.V. Melnik, I.V. Babachenko, A.S. Levina // Voprosy Prakticheskoy Pediatrii. — 2011. — Т. 6, №3. — S. 23—29. (In Russ).
9. Karpova E.P. O roli razlichnyhetiologicheskih faktorov v razvitii hronicheskoy patologii nosoglotki u detey [About the role of the various etiological factors in the development of chronic diseases of the nasopharynx in children] / E.P. Karpova, D.A. Tulupov // Lechashchiy Vrach. — 2013. — № 1. — S.26—28. (In Russ).
10. Melnik O.V. Patogeneticheskie aspekty formirovaniya chastyh respiratornyh zabolevaniy u detey s tsitomegalovirusnoy i Epshteina-Barr virusnoy infektsiiey [Pathogenetic aspects of the formation of frequent respiratory diseases in children with cytomegalovirus and Epstein-Barr virus infection ] / O.V. Melnik, I.V. Babachenko, A.S. Kvetnaya, A.S. Levina // Zhurnal Infektologii. 2011. — T.3., №4. — S.67—73. (In Russ).
Review
For citations:
Levina A.S., Babachenko I.V. PERSISTENT INFECTION IN FREQUENT AND PROLONGED ILL CHILDREN, POSSIBILITIES OF ETIOPATHOGENETIC THERAPY. CHILDREN INFECTIONS. 2014;13(4):41-45. (In Russ.) https://doi.org/10.22627/2072-8107-2014-13-4-41-45
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