Comparative analysis of hemostatic disorders in bacterial and viral neuroinfections at a children
https://doi.org/10.22627/2072-8107-2020-19-2-5-13
Abstract
Purulent meningitis and viral encephalitis are the most common neuroinfections in children. The severity of the lesion, the frequency of disabling manifestations, as well as high mortality, determine the relevance of their study. Violations of hemostasis both in purulent meningitis and in viral encephalitis are some of the important pathogenetic mechanisms that determine the nature of the course and the similarity of the disease.
The material for clinical, laboratory, and radiation studies was 100 children with purulent meningitis of various etiologies and viral encephalitis from the age of 1 month to 17 years 11 months. In addition to clinical monitoring, all patients underwent D-dimer and circulating endotheliocytes in the acute period and disease dynamics. The different nature of vascular damage has been proved: with the prevalence of endothelial damage in purulent meningitis, and a violation of its functional activity with vascular tone dysfunction — in case of viral encephalitis.
Radiation markers of cerebral vascular damage in the acute period of neuroinfections are described. The pathogenetic significance of structural and functional disorders of the vascular wall and hemostasis in the genesis of purulent meningitis and viral encephalitis in children has been established.
The material for clinical, laboratory, and radiation studies was 100 children with purulent meningitis of various etiologies and viral encephalitis from the age of 1 month to 17 years 11 months. In addition to clinical monitoring, all patients underwent D-dimer and circulating endotheliocytes in the acute period and disease dynamics. The different nature of vascular damage has been proved: with the prevalence of endothelial damage in purulent meningitis, and a violation of its functional activity with vascular tone dysfunction — in case of viral encephalitis.
Radiation markers of cerebral vascular damage in the acute period of neuroinfections are described. The pathogenetic significance of structural and functional disorders of the vascular wall and hemostasis in the genesis of purulent meningitis and viral encephalitis in children has been established.
About the Authors
E. S. Egorova
Pediatric Research and Clinical Center for Infectious Diseases
Russian Federation
PhD
Saint-Petersburg
Russian Federation
PhD
Saint-Petersburg
N. V. Skripchenko
Pediatric Research and Clinical Center for Infectious Diseases; Saint-Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
Natalya Skripchenko, MD, Professor, Deputy Director for Research of the Children's Scientific and Clinical Center for Infectious Diseases of FMBA of Russia; Head of the Department of Infectious Diseases of St. Petersburg State Pediatric Medical University of the Ministry of Health of Russia
Saint-Petersburg
А. А. Vilnits
Pediatric Research and Clinical Center for Infectious Diseases; Saint-Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
PhD
Saint-Petersburg
L. A. Alekseeva
Pediatric Research and Clinical Center for Infectious Diseases
Russian Federation
Russian Federation
MD
Saint-Petersburg
E. Yu. Skripchenko
Pediatric Research and Clinical Center for Infectious Diseases; Saint-Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
MD
Saint-Petersburg
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Review
For citations:
Egorova E.S., Skripchenko N.V., Vilnits А.А., Alekseeva L.A., Skripchenko E.Yu. Comparative analysis of hemostatic disorders in bacterial and viral neuroinfections at a children. CHILDREN INFECTIONS. 2020;19(2):5-13. (In Russ.) https://doi.org/10.22627/2072-8107-2020-19-2-5-13
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