Infectious mononucleosis: atypical manifestation
https://doi.org/10.22627/2072-8107-2022-21-1-62-65
Abstract
In most cases, EBV mononucleosis in hospitalized children occurs in a typical form, with a classical clinical picture. Cases of hepatitis, as the leading syndrome in EBV infection, are extremely rare. The article presents a clinical case of atypical onset of infectious mononucleosis of EBV etiology, which started with liver damage syndrome. This clinical experience gives an opportunity to run diagnostics of herpesvirus infections in cases of nonspecific liver damage.
About the Authors
V. A. Greshnyakova
Children's Research and Clinical Center for Infectious Diseases
Russian Federation
Russian Federation
PhD
Saint Petersburg
L. G. Goriacheva
Children's Research and Clinical Center for Infectious Diseases;
Saint Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
MD
Saint Petersburg
A. O. Nikiforova
Children's Research and Clinical Center for Infectious Diseases
Russian Federation
Russian Federation
Saint Petersburg
References
1. Demina O.I., Tikhomirov D.S., Chebotarеva T.A., Mazankova L.N., Tupolevа T.A. Clinical relevance of virological verification methods for the etiology of infectious mononucleosis. Detskie Infektsii=Children's Infections. 2020; 19(2):29—37. (In Russ.) doi.org/10.22627/2072-8107-2020-19-2-29-37
2. Hakizimana J.K., Timchenko V.N., Shakmaeva M.A., Kaplina T.A., Subbotina M.D., Bannova S.L., Fedorova A.V., Sukhovetskaya V.F., Pavlova E.B., Pavlov N.V. EBV mononucleosis in children in modern conditions. Detskie Infektsii=Children's Infections. 2020; 19(2): 23—28. (In Russ.) doi.org/10.22627/2072-8107-2020-19-2-23-28
3. Kang MJ, Kim TH, Shim KN, Jung SA, Cho MS, Yoo K, Chung KW. Infectious mononucleosis hepatitis in young adults: two case reports. Korean J Intern Med. 2009 Dec; 24(4):381—7. doi: 10.3904/kjim.2009.24.4.381
4. Herold J, Grimaldo F. Epstein-Barr Virus-induced Jaundice. Clin Pract Cases Emerg Med. 2020 Jan 21; 4(1):69—71. doi: 10.5811/cpcem.2019.10.45049.
5. Kang MJ, Kim TH, Shim KN, Jung SA, Cho MS, Yoo K, Chung KW. Infectious mononucleosis hepatitis in young adults: two case reports. Korean J Intern Med. 2009 Dec; 24(4):381—7. doi: 10.3904/kjim.2009.24.4.381.
6. Tezer H, Kanık Yüksek S, Gülhan B, Özkaya Parlakay AN, Tuna Kırsaçlıoğlu C. Cytomegalovirus hepatitis in 49 pediatric patients with normal immunity. Turk J Med Sci. 2016 Dec 20; 46(6):1629—1633. doi: 10.3906/sag-1507-161.
7. Schechter S, Lamps L. Epstein-Barr Virus Hepatitis: A Review of Clinicopathologic Features and Differential Diagnosis. Arch Pathol Lab Med. 2018 Oct; 142(10):1191—1195. doi: 10.5858/arpa.2018-0208-RA.
8. Neverov V.A., DemidenkoT.P., Vasiliev V.V. Herpesvirus infections caused by lymphotropic viruses. Part III. Russian Family Doctor. 2018. No.1. doi:10.17816/RFD201815-11
9. Khoo A. Acute cholestatic hepatitis induced by Epstein-Barr virus infection in an adult: a case report. J Med Case Rep. 2016 Mar 27; 10:75. doi:10.1186/s13256-016-0859-x
10. Zhang W, Chen B, Chen Y, Chamberland R, Fider-Whyte A, Craig J, Varma C, Befeler AS, Bisceglie AM, Horton P, Lai JP. Epstein-Barr Virus-Associated Acute Liver Failure Present in a 67-Year-Old Immunocompetent Female. Gastroenterology Res. 2016 Oct; 9(4-5): 74—78. doi: 0.14740/gr718e
11. Alli A, Nabil F, Ortiz J. Infectious Mononucleosis: A Case Report With Unusual Features and Abnormal Laboratory Findings. Cureus 2021 May 13(5): e14790. doi: 10.7759/cureus.14790
12. Park MJ, Chung IK, Park YD, Chung YJ, Lee HC, Cho HJ, Seo EH, Cho CM, Tak WY, Kim SK, Choi YW, Kweon YO. A case of cholestatic hepatitis induced by epstein-barr virus infection. Korean J Hepatol. 2006 Jun; 12(2):237-42.
13. Nogueira, Mayara Gaspar, Joana Gomes, Susana.Cholestatic hepatitis as a presentation of Epstein-Barr virus infection. International Journal of Medical Reviews and Case Reports. 2021. 5(5):39—4. doi: 10.5455/IJMRCR.Epstein-Barr-virus-infection-058
14. Bunchorntavakul C, Reddy KR. Epstein-Barr Virus and Cytomegalovirus Infections of the Liver. Gastroenterol Clin North Am. 2020 Jun; 49(2):331—346. doi: 10.1016/j.gtc.2020.01.008.
Review
For citations:
Greshnyakova V.A., Goriacheva L.G., Nikiforova A.O. Infectious mononucleosis: atypical manifestation. CHILDREN INFECTIONS. 2022;21(1):62-65. (In Russ.) https://doi.org/10.22627/2072-8107-2022-21-1-62-65
Views:
610
Email this article 