Experience of using inhaled steroid therapy in children with whooping cough

Abstract

The aim of study: аnalysis of the effectiveness of inhaled steroid therapy in patients with whooping cough.

Materials and methods: 74 patients with whooping cough were observed, among whom 40 children included inhalations with Budesonide in complex therapy (main group). 34 patients in the comparison group received only basic therapy. The age structure in the main group was as follow: тhere were children under one years old 18 (47.4 ± 8.1%), 1—3 years — 7 (18.4 ± 6.3%); 4—6 years — 8 (21 ± 6.6%), 7—14 years — 7 (13.2 ± 5.5%) and comparable to the comparison group. To verify whooping cough were used the PCR method and serological diagnostic (IFA) using a test system “Ridascreen/Bordetella pertussis («R-biofarm AMG», Germany). Results: budеsonide was prescribed for a course of 5—7 days. Clinical analysis of dynamics of cough in main group showed, that a reduction in a number of attacks by the 4—5th day of budesonide was observed in majority of children (35/87.5 ± 5.2%). In the main group coughing attacks with a frequency of more than 15—25 times a day persisted for 2.7 ± 0.2 days, and in comparison group — 4.3 ± 0.2 (p < 0.001). Relief of broncho-obstructive syndrome was observed in shorter period of time, which contributes to a reduction in the average length of stay of the patient in the hospital.