The article is devoted to the study of clinical symptoms and laboratory changes at parvovirus B19 infection in children during the rise of the incidence of infectious erythema. 44 children ailing with laboratory confirmed parvovirus B19 infection aging from 2 months to 14 years were complexly examined. It was established that the disease occurs mainly in boys of preschool and early school age, with a seasonal rise in April and May. General infectious syndrome and syndrome of exanthema dominate the clinical picture. Infectious erythema has benign course.

The article presents data obtained during the observation of 18 children who had suffered fromWest Nileencephalitis. It is shown that WNE in theLower Volgaregion is characterized by extremely low morbidity in children. Unlike adults, the main clinical form of WNE in childhood is acute fever without damage to the central nervous system. The authors highlighted the leading clinical and laboratory syndromes: prolonged fever, neutrophilic leukocytosis, high frequency of secondary purulent bacterial complications.

We estimated the safety of the vaccination for prevention of influenza with Grippol® plus vaccine alongside with vaccination with combined preparations for the prevention of diphtheria and tetanus (Td) and measles, rubella, mumps in children aged 6—7 years. We determined that combined immunization with the indicated vaccines proves good tolerability and low reactogenicity. Vaccine Grippol® Plus shows low reactogenicity , high immunologenicity and does not cause cross-suppression of antibodies in co-administration with other vaccines on vaccination calendar. Also concomitant vaccination with Grippol® plus and other vaccines does not inhibit the development of a specific immune response against influenza.

In the article we describe different modern methods of estimation of liver fibrosis at chronic viral hepatitis and their role in clinical practice.

Influenza is one of the most dangerous infection for children of early age. Vaccine-prophylactics against influenza is the most important way to confine the spreading of the infection and to localize epidemic outbreak among children. Modern vaccines have a high level of safety and efficacy. It allows to apply them during the first year of life. The WHO and ECDC point out the necessity of group and individual immunity development among children of different age groups. The authors demonstrated important role of immunization against influenza for the mother to enhance resistance to the infection in the child in the first months of its life.

We carried out the analysis of researches devoted to the treatment of children with chronic adenoiditis and hypertrophy of adenoid vegetations. We proved that the usage of topic immunomodulator IRS19 incombination with etiotropic treatment allows to sanate lymphoid tissues in nasopharynx effectively and to preserve its continuity as an important organ supplying unspecific and specific protection of the child’s organism.

The work presents the results of observation of the dynamics of the ARVI indicators in children of Aktobe city and the Aktyubisk region for the period of 2006— 2010, also ethnological structure and age composition of children. The authors also speak about clinical efficacy of combined application of Viferon preparation with differential choice of dozes and the duration of course of treatment for children with ARVI and recurrent disease.

The new rapid molecular genotyping method was developed for studying the structure of ptxP promoter of pertussis toxin. Method is based on PCR-RFLP analysis, which allows studying the specific restriction profiles of the B. pertussis strains and allows differentiation of the strains with the ptxP structural particularities. The developed method for genotyping of strains of B. pertussis can be hhelpful when monitoring strains of the causative agent of whooping cough in system of an epidemiological surveillance over pertussis infections, allowing observation over circulating population of B.pertussis, revealing strains of the causative agent of whooping cough with high production of pertussis toxin and to watch their distribution.

Cervical lymphadenopathy is a very frequent diagnosis in pediatric practice. Most of the cases of lymph nodes enlargement in children are not associated with severe, life-threatening diseases. However, in some patients lymphadenopathy is an easily accessible indicator for early diagnosis of a serious illness. Early detection of such indicators can often save a child’s health and even life. This article details the main infectious causes of cervical lymphadenopathy in children. The algorithm of the diagnostic is presented.

The authors presented a review of literature of necrotizing fasciitis in children. A rare case of necrotizing fasciitis in 3-year-old child is described. The difficulties of differential diagnostics of the given disease are presented.

Federal Service on Customers' Rights Protection and Human Well-Being Surveillance in Orenburg Region, Orenburg The authors presented the results of the clinical and epidemiological analysis of enterovirus coxsackievirus A-16 group morbidity among kindergarten children in the Orenburg region occurring in the form of the syndrome of ≪hand-foot-mouth≫ with exantem. 20 children were involved in the epidemic process, 72,2% of the children are 1—2 years old, they became a source of infection to other groups of children. The disease had a mild course and did not require special treatment.

Bacterial purulent meningitis (BPM) was detected and treated in 63children aged from 1 month till 17 years during 2006—2010. 63,5% (40 patients) of patients were children of first three years old. In this group etiological distribution of the children was as follows: 55% were meningococcal, 17,5% were hemophilic, 2,5% were esherichiosic, 2,5% were staphylococcal, 22,5% were of unclear etiology. The peculiarities of clinics, causes and treatment of Hib — meningitis were explored in 7 children. The criteria were found which indicate the possibility of prolonged wave-like course of Hib-meningitis in the acute period of the disease.

The authors analyzed 254 cases of Enteroviral Meningitis (EVM) in children that were treated in the children's department of neuroinfections ofClinicalHospital№40 inClinical andDiagnosticCenter. We compared the conventional method of the treatment of EVM in children above three years with complex therapy that includes various immunotropic preparations. The efficiency of the therapy was estimated according to the results of clinical observations, and the parameters of systemic immunity. Basic therapy included the appointment of rehydration, vasoactive drugs, vitamins of group B. In comparison groups children were given one of the following preparations: Amixin, Anaferon for children, Cycloferon, Viferon in addition to the basic treatment. The study demonstrated the benefits of complex treatment for enteroviral meningitis with immunomodulators before applying basic therapy. Total maximum effect was observed in the group with Anaferon for children.

Adolescent girls suffering from respiratory diseases have disorders in the formation of their reproductive systems. Dysmenorrhea is the most frequent element in the structure of reproductive abnormalities. Girls with respiratory diseases have a lower quality of life related to health, except for social functioning.