Metabolic disorders lead to admission into the bloodstream of a large number of toxic substances medium molecular weight, the concentration of which increases in respiratory diseases. Objective: determine the level of molecules of average and low mass, peptides in the serum of in infants with pneumonia and ARVI. Determination of the level of molecules of average and low weight, and the content of the peptides in the serum was performed screening methodin infantswith pneumonia (31 children) and ARVI (37 children). There were 20 healthy children in control groupof the same age.In the acute period of the disease the level MSINM and peptides was significantly increased as in pneumonia, and ARVI. The highest values were observed during the study content of peptides. In addition to a clear dependence of the concentration of MSINM and peptides from the severity of infectious toxicosis found a significant difference between these parameters when comparing toxic syndrome with pneumonia and ARVI. Parameters of MSINM and peptides can be used as diagnostic criteria of pneumonia, ARVI and intensity of infection toxicosis.

The article presents data on the design of different influenza vaccines, as well as safety, immunogenicity and efficacy of a new national preventive virosomal? vaccine ULTRIKS®. It is shown that the vaccine is high-immunogenic preventive medications and may be recommended for annual preventive vaccination of children and adults against influenza, primarily of persons at higher risk of infection and the incidence of influenza and SARS, people older than 60 years, and persons with secondary immunodeficiency states.

The results of the search of the features during the child chickenpox hospitalized in the Orenburg Regional Clinic (infection hospital) during the period of time from 2010 to 2013 shows the dynamic objectives and their amount during this period of time, the structure of the main composition and complications, and also the characteristic of the breakout of the chickenpox in the Regional Child House with the mark of efficiency provided by vaccination against the chickenpox in this institution. It is declareted, that during the period the number of children hospitalized to the stationary and frequaency of the complications increasing annually. In the epidemic process of the varicella in the Child House have been involved 57 out of 66 children and the lifetime of the breakout was 128 days. The vaccination against the varicella was highly effective.

In 60 patients with moderate forms of the OCI «osmotic» (76.7%) and «invasive» (23.3%) such as diarrhea, aged 3—12 years, to evaluate the clinical effectiveness, impact on water and electrolyte metabolism, acid-base balance and intestinal microbiocenosis hypoosmolyarny solution with Lactobacillus rhamnosus GG «Regidron Bio» (30 patients) and hyperosmolarny solution (30 patients). It was found that in the group of patients receiving «Regidron Bio», in contrast to the hyperosmolarny solution, is rapidly disappearing symptoms of intoxication and exsicosis, abdominal pain, meteorism and liquid watery diarrhea. The average duration of the acute period is reduced from 4,06 ± 0,32 to 3,07 ± 0,27 day (P < 0,05). Already by the end of the 1st day of the beginning of rehydration, almost all patients (90%) are normalized malformations of blood electrolytes and glucose, hematocrit, and on the 2nd day, which took place in 80% of patients with metabolic acidosis. The addition of the «Bio rehydron» Lactobacillus rhamnosus GG facilitates, unlike hyperosmolarny solution indicator normalizing lg Lactobacilli (in 73.3%) and Enterococci (93.3%), but has no significant positive impact on the amount of Bifidobacteria and Escherichia coli.

In the article results of a randomized comparative multicenter study of the clinical and microbiological efficacy and safety of azithromycin (Sumamed) and cefixime (Suprax) 185 children aged 1—14 years with moderate (70.8%) and severe forms (29.2%) of acute intestinal infections with invasive type of diarrhea. Etiological diagnosis microbiological method was detected in 48 (25.9%) patients, including salmonellosis in 85.4% of cases sonnei shigellosis or Flexner in 14.6% of patients. Found that both drugs have a high clinical efficacy (of 86.2% and 87.2%, respectively). While, microbiological efficacy of azithromycin was significantly higher (83.3%) than of cefixime (58.3%) (p < 0.001), including, when salmonellosis she reached 81.8% and that of cefixime, only 52.6% of patients. A clinical study confirmed the safe use of these antimicrobial agents in the treatment of acute intestinal infections in children.

80 patients were observed with infectious mononucleosis (IM) from 2 to 12 years. Diagnosis was confirmed by the definition of M- and G-antibodies to EBV, CMV, HHV6, PCR DNA these viruses, bacteriological and blood-tests investigations. 40 patients was given bifidumbacterin forte 45—90 doses a day and cycloferon 8 mg/kg/weight a day(1-st group). The comparison group consisted of 40 patients with IM receiving symptomatic therapy and antibiotics (2-nd group). The observations shoved significant decreasing of length of clinical symptoms IM in the 1-st group with comparison of the 2-nd group. The obtained results allow to recommend bifidumbacterin forte and cycloferon in the complex therapy in children with infectious mononucleosis.

The article contains current data on the age-dependent physiological features of children’s immunity. Special attention is given to the specific stages of humoral and cell mediated immunity formation, critical periods of increased risk of infections and other pathology are noted. Also, the article defines the factors affecting immune system development, such as breastfeeding, balanced nutrition, different types of cold training and harmfulness of irrational antibiotic therapy. Particular reference is made to the role of interferons in increasing functional activity of the immune system and the improvement of immune disturbances.

Syphilis remains one of the very disturbing inflections. The highest morbidity rate is registered among women at the age of 18—29 years old. The percentage of pregnant women in the General statistics of syphilis incidence is 8 to 12%. Against this background, the syphilis incidence among newborn infants is an extremely serious problem. The article presents the clinical case of early congenital syphilis in the newborn baby.

Children and teenagers observed in IV and VI groups dispensary of the account in Republican clinical tubercular hospital per 2005—2009 years among 150 men separated into two subgroups. The influence of risk factors on a case rate by tuberculosis with the help of mathematical technologies is revealed. In effect the degrees of hazard of disease by a tuberculosis are allocated, on the basis of that the computer program designed, which is guided on definition of an individual degree of hazard on a tuberculosis at children both teenagers and reception of the references on carrying out different preventive antituberculosis of measures.

The lecture is devoted to the problem of differential diagnosis of infectious exanthemas in children. Information about differential-diagnostic sings of infectious and non-infectious exanthemas is present. Differential diagnosis is proposed on the basis of morphological elements identified in objective research. Presents possible infectious and non-infectious causes of rashes which are characterized by different primary (spot, papula, blister, knob, knot, bubble, abscess, bladder) and secondary (scale, erosion, ulcer) morphological elements.

The article describes modern methods of teaching needed to ensure and improve the learning process, while maintaining traditional ways of learning. Character-ized by control methods to ensure the educational process, argues conducting educational monitoring and presents a contemporary view of the problem of quality of education in high school, in terms of its reform intensification of training in high school are invited to spend, using the elements of the educational process of constructive pedagogy.

In this article development of mathematical model of diagnosis of sharp intestinal infections in newborn children depending on the nature of the infectious agent is described. All risk factors promoting development of intestinal infections were considered. By means of a method of logical regression the medico-mathematical model the express of diagnosis of sharp intestinal infections in newborn children was developed.

A case of generalized enteroviral infection of a newborn (encephalomyocarditis and dilated cardiomyopathy) was described. The 6 day old patient required close monitoring and intensive care because of severe heart failure. Diagnosis of enteroviral infection was made by detection of enterovirus RNA in the sterile body fluids — blood and cerebrospinal fluid.